SOX4与白血病关系的研究进展  

Progress of SOX4 in leukemia

作　　者：段培锋[1] 贾秀红[1] 

机构地区：[1]滨州医学院附属医院儿科,256603

出　　处：《国际儿科学杂志》2015年第2期173-176,共4页International Journal of Pediatrics

基　　金：山东省科学技术发展计划项目（2010GSF10264）

摘　　要：白血病是多基因参与的造血系统恶性增殖性疾病,白血病相关致病基因及基因治疗是目前研究的热点.SOX4基因是SOX C亚族的成员之一,在肺癌、乳腺癌、肝癌、胃癌、髓母细胞瘤等多种人体肿瘤的发生、发展中起重要作用.近年来研究发现,SOX4基因对白血病的发生、治疗及预后评估均有重要意义.该文就SOX4的结构和功能、在白血病中的表达、作用机制以及对白血病治疗和预后的影响等方面作一综述.Leukemia is a polygenic malignant proliferative disease in the hematopoietic system.Its possible causative genes and gene therapy are one hotspot of the current researches.Sex-determining region Y-related high-mobility-group box transcription factor 4（SOX4） is a member of the group C subfamily of the SOX transcription factors,playing a critical role in the occurrence and development of many tumors such as lung cancer,breast cancer,hepatic carcinoma,gastric cancer and medulloblastoma.Recently,researches have found that SOX4 is significant in the occurrence,treatment and prognosis evaluation of leukemia.This paper reviews the structure and functions of SOX4,its expression and mechanism in leukemia,and its influence on leukemia treatment and prognosis.

关 键 词：SOX4基因 白血病 

分 类 号：R733.7[医药卫生—肿瘤]