中国乳腺癌患者VEGF-C表达与临床意义关系的Meta分析  

Association between VEGF-C expression and clinical significance in Chinese breast cancer patients:a Meta-analysis

作　　者：和珂莉 曾慧[1] 方程[1] 谢文[1] 张莉[1] 潘中亚 龙行华[1] 

机构地区：[1]武汉大学中南医院检验科,湖北武汉430071

出　　处：《国际检验医学杂志》2015年第6期723-725,728,共4页International Journal of Laboratory Medicine

基　　金：国家自然科学基金资助项目(30873044;81272372);教育部留学回国人员科研启动基金资助项目(教外司留[2011]1139号)

摘　　要：目的系统评价国内有关乳腺癌组织中血管内皮生长因子C（VEGF-C）表达与临床意义的关系。方法计算机检索中国学术期刊全文数据库（CNKI）、生物医学文献数据库（CBM）、中文科技期刊全文数据库（VIP）、万方数据库并辅以文献追溯的方法,收集公开发表的有关VEGF-C表达与乳腺癌临床表现的病例对照研究。检索年限均从建库至2014年6月。按纳入排除标准筛选文献并评价纳入研究质量后,应用RevMan5.2软件进行Meta分析。结果共纳入15个病例对照研究,共计975个病例。Meta分析结果显示VEGF-C在乳腺癌组与对照组[OR=8.16,95%CI（5.77,11.54）]、乳腺癌淋巴结转移阳性组与阴性组[OR=5.19,95%CI（3.63,7.44）]及临床Ⅰ~Ⅱ期与临床Ⅲ~Ⅳ期组[OR=0.35,95%CI（0.21,0.59）]的表达差异均有统计学意义;在0~〈50岁组和大于或等于50岁组的VEGF-C表达差异无统计学意义[OR=1.02,95%CI（0.68,1.53）],提示VEGF-C的表达与患者年龄无明显关联。结论目前证据证明VEGF-C可能参与乳腺癌淋巴结转移等发生发展的过程,并可能成为影响乳腺癌预后的重要因素。Objective To systematically evaluate the association between vascular endothelial grow th factor‐C （VEGF‐C） ex‐pression in breast cancer tissue and clinical significance in the domestic patients with breast cancer by a Meta‐analysis .Methods The published case controlled trials on the VEGF‐C expression and the clinical manifestations of breast cancer were retrieved from the CNKI ,CBM ,VIP and Wanfang databases ,and other relevant journals were also manually retrieved to identify all the relevant case controlled trials .The retrieval year limit was from the database establishment to June 2014 .The included literatures were screened according to the inclusion and exclusion standards and the quality of included case controlled trials was assessed .The Rev‐Man 5 .2 software was used to conduct the Meta analysis .Results A total of 15 case controlled trials involving 975 patients with breast cancer were included .The Meta analysis results revealed that there were statistical differences in the VEGF‐C expression be‐tween the breast cancer group and the control group[OR = 8 .16 ,95% CI（5 .77 ,11 .54）] ,between the lymph node metastasis posi‐tive group and the non‐lymph node metastasis negative group[OR = 5 .19 ,95% CI（3 .63 ,7 .44）] and between the clinical stage Ⅰ -Ⅱ group and the stage Ⅲ - Ⅳ group[OR = 0 .35 ,95% CI（0 .21 ,0 .59）] ;the difference in the VEGF‐C expression between the 0 - 〈50 years group and the ≥ 50 years group had no statistical significance ,indicating that the VEGF‐C expression had no obvious as‐sociation with the patient′s age .Conclusion The present evidences reveal that VEGF‐C maybe participate in the development and progression process of lymph node metastasis of breast cancer and may be become an important factor influencing the prognosis of breast cancer .

关 键 词：乳腺癌 血管内皮生长因子C META分析 

分 类 号：R737.9[医药卫生—肿瘤] R730.43[医药卫生—临床医学]