7652例血红蛋白电泳结果分析及意义  

Analysis and significance of results of hemoglobin electrophoresis in 7 652 cases

作　　者：易旺云[1] 袁明生[2] 

机构地区：[1]广东医学院附属陈星海医院妇产科,广东中山528415 [2]广东医学院附属陈星海医院检验科,广东中山528415

出　　处：《国际检验医学杂志》2015年第6期751-752,共2页International Journal of Laboratory Medicine

摘　　要：目的了解中山小榄地区血红蛋白病的检出率及其类型,为优生优育提供参考依据。方法选取2010年6月至2013年12月来该院进行孕期检查孕妇7 652例,采用法国SEBIA公司生产的HYDRASYS自动血红蛋白电泳仪进行血红蛋白(Hb)电泳,扫描出Hb各组成分并进行统计学分析。结果7 652例标本中,筛查出1 057例疑似血红蛋白病患者,检出率13.81%,其中Hb A2<2.0%(疑似α地中海贫血)患者511例(6.68%);Hb A2>3.5%(疑似β地中海性贫血)患者451例(5.89%),低于前者的检出率,差异有统计学意义(P<0.05)。Hb C或E检出11例(0.14%),Hb J或K检出9例(0.12%),Hb H带8例(0.10%),Hb Bart′s带7例(0.09%),其余Hb CS带1例,Hb G带2例,HB D带1例,共占0.04%。结论 Hb电泳可以较好的筛查血红蛋白病,在该地区应尽早进行血红蛋白病筛查,对优生优育具有重大意义。Objective To investigate the detection rates and types of hemoglobinopathy in Xiaolan district of Zhongshan city to provide the basis for prepotency .Methods 7 652 pregnant women with pregnancy detection in our hospital from June 2010 to De‐cember 2013 were selected and performed the electrophoresis by the Hydrasys automatic hemoglobin electrophoresis system .The hemoglobin components were scanned out and performed the statistical analysis .Results Among 7 652 samples ,1 057 cases of sus‐pected hemoglobinopathy were screened out with the detection rate of 10 .36% .Among them ,511 cases（6 .68% ） were Hb A2 〈2 .0% （suspected α‐thalassemia） ,451 cases（5 .89% ） were Hb A 〉 3 .5% （suspected β‐thalassemia） ,the detection rate of Hb A2 〉3 .5% was lower than that of Hb A2 〈2 .0% ,the difference had statistical significance（P〈0 .05） .11 cases （0 .14% ） were Hb C or E ,9 cases （0 .12% ） were Hb J or K ,8 cases （0 .10% ） were Hb H ,7 cases （0 .09% ） were Hb Bart′s ,1 case was Hb CS ,2 cases were Hb G and 1 case was Hb D ,which accounted for 0 .04% .Conclusion Hemoglobin electrophoresis can screen hemoglobinopa‐thy effectively .The hemoglobinopathy screening in this area should be conducted as soon as possible ,which has an important signif‐icance to prepotency .

关 键 词：血红蛋白 琼脂糖凝胶电泳 血红蛋白病 

分 类 号：R446.11[医药卫生—诊断学]