C-12蛋白芯片检测系统的临床应用价值  

Clinical application value of C-12 protein chip detection system

作　　者：刘小玲[1] 马珏欣[1] 

机构地区：[1]北京市丰台区方庄社区卫生服务中心检验科,北京100078

出　　处：《国际检验医学杂志》2015年第6期798-800,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨多肿瘤标志物蛋白芯片系统(C-12)在临床应用中的价值。方法测定分析5 000例健康人群(健康体检组)、4 500例良性肿瘤及炎症患者(良性疾病组)、5 500例恶性肿瘤患者(恶性肿瘤组)的12种常见肿瘤标志物的水平。同时对恶性肿瘤组的1 369例阴性标本采用全自动化学发光免疫分析仪运用电化学发光法进行比对分析。结果 C-12对恶性肿瘤组的阳性率为75.11%,显著高于良性疾病组的20.31%和健康体检组的4.34%,各组间两两比较差异有统计学意义(P<0.05)。C-12对恶性肿瘤检测的灵敏度为75.11%,特异度为95.66%,联合检测的阳性率均显著高于单一标志物,差异有统计学意义(P<0.05)。结论 12项肿瘤标志物蛋白芯片法联合检测对肿瘤患者的诊断有一定参考价值,检测多种肿瘤标志物可以明显提高恶性肿瘤诊断的敏感性,可应用于预后及疗效观察,同时也可以作为无症状人群的早期肿瘤普查手段之一。Objective To study the value of the multiple tumor markers protein chip system （C‐12） in the clinical application . Methods The levels of 12 kinds of tumor markers were detected in 5 000 healthy people （healthy physical examination group） ,4 500 patients with benign tumor and inflammation （benign disease group） and 5 500 patients with malignant tumors （malignant tumor group） .At the same time 1 369 negative specimens in the malignant tumor group were performed the comparative analysis with the electrochemiluminescence method by adopting the fully automatic chemiluminescence immune analyzer .Results The posi‐tive rate in the malignant tumor group by using C‐12 was 75 .11% ,which was significantly higher than 20 .31% in the benign dis‐ease group and 4 .34% in the healthy physical examination group ,the difference between the two groups in pair had statistical sig‐nificance（P〈0 .05） .The sensitivity of C‐12 for detecting malignant tumor was 75 .11% ,the specificity was 95 .66% ,and the posi‐tive rate of joint detection was significantly higher than that of single marker ,the difference between them was statistically signifi‐cant （P〈0 .05） .Conclusion The 12 tumor markers protein chip joint detection method has certain reference value for the diagnosis in the patients with tumor .Detecting multiple tumor markers can obviously increase the diagnosis sensitivity of malignant tumors , can be used in the prognosis and the curative effect observation ,at the same time can also be used as one of screening measures for early tumor among asymptomatic population .

关 键 词：蛋白芯片 肿瘤标志物 恶性肿瘤 

分 类 号：R730.43[医药卫生—肿瘤]