食管鳞状细胞癌中VEGF、P53及Ki-67的表达及临床意义  

Expression of VEGF,P53 and Ki-67 in Esophageal Squamous Cell Carcinoma and Its Clinical Significance

作　　者：刘汉忠[1] 杨继洲[1] 肖兰[1] 何慧华[1] 王岚[1] 

机构地区：[1]湖北省孝感市中心医院,432000

出　　处：《实用癌症杂志》2014年第4期385-386,共2页The Practical Journal of Cancer

摘　　要：目的探讨血管内皮生长因子(VEGF)、P53及Ki-67在食管鳞状细胞癌发生、发展中的作用。方法采用免疫组织化学染色SP法检测43例食管鳞状细胞癌组织和20例食管癌旁组织中VEGF、P53及Ki-67表达。结果 VEGF蛋白、P53及Ki-67在食管鳞状细胞癌中阳性率分别为90.7%、88.4%、100.0%,而在癌旁组织中低表达及不表达,2组比较P均<0.01;VEGF、P53及Ki-67阳性表达与临床病理特征之间关系研究发现VEGF、P53及Ki-67表达强弱与癌组织分化程度(γ=0.945、0.963、0.986,P均<0.05)呈正相关。结论 VEGF、P53及Ki-67在食管鳞状细胞癌组织中的表达显著升高,其可能与食管鳞状细胞癌的发生、发展密切相关。Objective To investigate the effect of vascular endothelial growth factor （VEGF）,P53 and Ki-67 in the oc-currence and development of esophageal squamous cell carcinoma .Methods Expression of VEGF ,P53 and Ki-67 in 43 cases of esophageal squamous cell carcinoma and 20 cases of adjacent cancer tissues were detected by immunohistochemistry SP method . Results In esophageal squamous cell carcinoma ,positive rates of VEGF protein ,P53 and Ki-67 were 90.7%,88.4%,100.0%. In the adjacent cancer tissues ,VEGF protein,P53 and Ki-67 had low expression or no expression ,P〈0.01：The relationship be-tween clinicopathologic features and expression of VEGF , P53 and Ki-67 showed that expression of VEGF , P53 and Ki-67 was positively related with tumor differentiation （γ=0.945,0.963,0.986,P〈0.05）.Conclusion The dramatic increase of VEGF, P53 and Ki-67 in esophageal squamous cell carcinoma may be closely related to the occurrence and development of esophageal squamous cell carcinoma .

关 键 词：食管鳞状细胞癌 血管内皮生长因子 P53 KI-67 

分 类 号：R735.1[医药卫生—肿瘤]