原发性腮腺恶性淋巴瘤10例临床分析  

Primary parotid lymphoma:clinical analysis of 10cases

作　　者：李斌[1,2] 许彭鹏[1] 赵维莅[1] 王黎[1] 刘占云[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院血液科,上海200025 [2]合肥市第一人民医院血液肿瘤科,合肥230001

出　　处：《临床血液学杂志》2014年第6期944-946,共3页Journal of Clinical Hematology

基　　金：国家自然科学基金(No:81101793;No:81325003);上海市科委基金(No:14430723400;No:14140903100)

摘　　要：目的:回顾性分析原发腮腺淋巴瘤的临床特点、诊治方法和预后情况。方法:收集本中心2004-01-2013-12原发腮腺淋巴瘤患者共10例。病理亚型为弥漫大B细胞淋巴瘤5例,黏膜相关淋巴组织淋巴瘤3例,滤泡性淋巴瘤2例。应用Kaplan-Meier法计算生存率。应用SPSS10.0统计学软件进行相关因素的统计和分析。结果:10例患者中男女比例为7∶3,中位年龄62岁。患者主要临床表现为腮腺、耳垂下、乳突、颌下无痛性肿块,5例累及左侧腮腺,5例为右侧累及,无患者出现双侧腮腺累及。按照Ann Arbor分期标准Ⅰ期30%(3/10),Ⅱ期20%(2/10)、Ⅲ期10%(1/10)、Ⅳ期40%(4/10);有B症状者30%(3/10)。手术+化疗6例,单纯化疗3例,单纯手术1例,完全缓解率100%。随访终点时间为2014年4月30日,中位随访时间36个月。2例进展,8例病情稳定;1例死亡,9例仍存活,5年累积总生存时间为80%。结论:腮腺淋巴瘤发病率低,病理类型多为B细胞型非霍奇金淋巴瘤,对化疗敏感,总体预后较好。Objective：To analyze the clinical features,therapeutic effect and prognosis of primary parotid lym- phoma （PPL）. Method： Ten PPL patients treated in Shanghai Rui Jin Hospital from January 2004 to December 2013 were enrolled in this study, including 5 diffuse large cell lymphoma, 3 mucosa-associated lymphoid tumor and 2 follicular lymphoma according to the WHO 2008 classification. Survival functions were estimated using the Kap lan-Meier method. All the results were analyzed by SPSS10.0. Result：Of the 10 PPI. cases, the ratio of male to fe- male was 7 ： 3 and the median age was 62 years old. The main clinical presentations of patients were painless mass of the parotid gland, the mastoid or submaxillary region. Ann Arbor stage at diagnosis was 30% Ⅰ E, 20%ⅡE, 10% ⅢE and 40% IgE,with 30% presenting B symptoms. Six patients were treated with surgery combined with chemotherapy,3 with chemotherapy only and 1 with surgery only. All patients achieved complete remission. Fol lowed-up till April 2014,with median follow-up of 36 months, 2 patients progressed with 1 died. Five-year overall survival was 80 %. Conclusion：PPL is a rare disease, with lymphoma cells mainly B-cell derived. Sensitive to chemo- therapy,PPL patients have good outcome.

关 键 词：原发腮腺淋巴瘤 病理分型 诊断 治疗 

分 类 号：R733.4[医药卫生—肿瘤]