大颗粒T-淋巴细胞白血病合并溶血性贫血1例并文献复习  

Large granular T-lymphocytic leukemia combined with hemolytic anemia:a case report and literature review

作　　者：罗静[1] 张王刚[1] 何爱丽[1] 王剑利[1] 

机构地区：[1]西安交通大学医学院第二附属医院血液科,西安710004

出　　处：《临床血液学杂志》2014年第6期992-993,共2页Journal of Clinical Hematology

摘　　要：大颗粒淋巴细胞白血病（large granular lymphocytic leukemia,LGLL）是以大颗粒淋巴细胞异常增多、中性粒细胞减少为主要血液系统改变的一种少见类型白血病。正常大颗粒淋巴细胞（LGL）占正常人外周血单个核细胞的10%~15%,其中大部分（85%）来自于CD3（-）NK细胞,小部分（15%）来自于CD3（＋）T细胞〔1〕。Summary This article reported a patient because of anemia,recurrent infections to the hospital. With Coombs test positive, he was in accordance with the hemolytic anemia treatment, the effect was not good. I.ater, the patient＇s anemia,infection symptoms gradually worsened,and the gradual emergence of systemic multiple lymph nodes, pe ripheral blood lymphocytes abnormal increased. TCR rearrangement was positive, bone marrow cells examinations showed large granular lymphocytes increased significantly. Then this patient was diagnosed with large granular lymphocyte leukemia and was given fludarabine-based chemotherapy combined cyclosporine suppresses the immune therapy,and achieved a significant effect.

关 键 词：大颗粒淋巴细胞白血病 溶血性贫血 免疫化学治疗 

分 类 号：R733.7[医药卫生—肿瘤]