基于双氯芬酸钠体外促渗的多路超声给药系统设计  

The Design of Multi-channel Ultrasonic Drug Delivery System in Promoting Diclofenac Sodium Infiltration

作　　者：刘伟[1] 胡志刚[1] 张兰兰[1] 张晓兰[1] 

机构地区：[1]河南科技大学医学技术与工程学院,河南洛阳471003

出　　处：《中国仪器仪表》2014年第12期46-50,共5页China Instrumentation

基　　金：河南省科技攻关项目;外置电场低频超声加速经皮给药系统的研制(编号:122102310276);河南科技大学校科研基金(编号:2013QN040);河南科技大学实验技术开发基金(编号:SY1213008)

摘　　要：开展基于超声促渗的双氯芬酸钠体外透皮影响的正交实验,提取复合促渗的有效参数组合,为适应后期动物实验和进一步临床测试的展开,需要基于该参数组合构建多通道超声给药系统。比对和分析了目前超声给药系统结构的主要实现方式,提出通用性多通道超声给药系统的构建方案,完成系统结构和电路的设计,为后续工作的展开提供了基础。We carried out the diclofenac sodium permeation experiment of ultrasound vitro transdermal influence with the orthogonal theory,then completed the experimental data accumulation and extracted the compound promotes effective parameters. In order to meet the needs of the late animal experiments and further clinical testing,we proposed to build the proper ultrasonic delivery drug system. In comparing and analyzing the main realization methods of ultrasonicator trans dermal system, the construction scheme is made for multichannel ultrasonic drug delivery system. We finally completed the system structure and circuit, providing the basis for subsequent work.

关 键 词：超声促渗 经皮给药 低频超声 

分 类 号：TQ460.1[化学工程—制药化工]