快速眼球运动睡眠剥夺对记忆和突触可塑性的影响及其分子机制的研究进展  

Review on the Impact of Rapid Eye Movement Sleep Deprivation on Synaptic Plasticity and its Molecular Mechanisms

作　　者：李炜[1] 李婷婷[1] 齐赛卿 张癸荣[3] 

机构地区：[1]河北北方学院药学系 [2]冀中能源峰峰集团总医院邯郸市峰峰矿区 [3]总后勤部卫生部药品仪器检验所

出　　处：《神经药理学报》2013年第4期47-57,共11页Acta Neuropharmacologica

基　　金：国家自然科学基金项目(No.81202192);河北省卫生厅项目(No.20130037);河北省教育厅项目(No.2010212)

摘　　要：睡眠不足是快节奏的现代社会人们需要面对的越来越严重的问题之一,而长期的睡眠不足又会导致认知功能障碍。睡眠剥夺会影响实验动物的学习记忆能力已得到广泛认可。本文回顾总结了近些年有关快速眼球运动睡眠剥夺对记忆和突触可塑性的影响及其分子机制的研究新进展,以期为相关治疗靶点和治疗药物的研究提供理论支持和启发。Insufficient sleep is an increasing serious problem to men and women in fastpaced modern society. Long-term insufficient sleep can lead to cognitive dysfunction. It has been widely recognized that sleep deprivation can affect the learning and memory ability of experimental animals. In this review, we summarized the new developments regarding the impact of rapid eye movement sleep deprivation on synaptic plasticity and its molecular mechanisms in recent years, which we hope can provide some basis for relevant studies of therapeutic targets and treatment drugs in future studies.

关 键 词：睡眠剥夺 记忆 突触可塑性 NMDA受体 腺苷 c AMP/PKA/CREB信号通路 MAPK/ERK信号通路 

分 类 号：R740[医药卫生—神经病学与精神病学]