俄罗斯沿海地区地球化学条件对碘缺乏所致甲状腺疾病分布的影响  

Effects of geochemical conditions on distribution of thyroid diseases due to iodine deficiency in seaside of Russia

作　　者：Kiku Pavel Fedorovich Pavel Fedorovich Fedorovich Grishchenko Vladimir Vladimirovich Vladimir Vladimirovich Vladimirovich Marina Viktorovna Yarygina Viktorovna Yarygina Yarygina 刘鹏[2] 刘守军[2] 刘岩[3] 孙殿军[2] 

机构地区：[1]俄罗斯远东联邦大学生物医学学院,海参崴690000 [2]哈尔滨医科大学中国疾病预防控制中心地方病控制中心 [3]哈尔滨医科大学基础医学院

出　　处：《中华地方病学杂志》2015年第3期186-191,共6页Chinese Journal of Endemiology

基　　金：哈尔滨医科大学中俄医学研究中心转化医学专项基金项目（CR201401）

摘　　要：目的 评估俄罗斯沿海地区居民甲状腺疾病的发病率与土壤中化学元素含量间的关系,了解毒性元素（镉、铅、砷、锡）和必需元素（镍、铁、钼、锌、硒、碘）对碘缺乏和碘缺乏病分布的影响.方法 采用“生态地理化学俄罗斯地图”项目中的“多功能地理化学地图（MGHK-1000）”数据,通过建立筛查指标的优先度,评估沿海地区土壤中的地理化学现状;采用基本的相关分析和二分类变量的逻辑分析,分析土壤中化学污染物和甲状腺疾病发病率间的关系,结合生态卫生学方法评估化学物质对甲状腺疾病发病率的影响.结果 俄罗斯沿海地区甲状腺疾病发病率近年增加;采用总污染指数可将调查地区分为7个大区;锌、铁、钴、锰失衡,铅、锶、镍、铬过量,也可引起碘缺乏.结论 甲状腺疾病发生与碘缺乏有关,与必需元素和毒性元素联合失衡有关.Objective To assess the relationship between environmental chemical elements and incidence of thyroid diseases in the population of primorsky region in Russia,to understand the effects between iodine deficiency,iodine deficiency diseases and toxic elements （cadmium,lead,arsenic,tin） and essential elements （nickel,iron,molybdenum,zinc,selenium,iodine）.Method By analyzing the project of ＂Multi-purpose geochemical mapping （MGHK-1000）＂,through the establishment of priority of screening indicators,the geochemical situation of seaside environment was evaluated; basic correlation analysis and logic analysis of binary type were used,combined with the eco-hygiene method to evaluate the relationship between environmental chemical pollutant and incidence of thyroid diseases.Results The prevalence of thyroid disease was increased in recent years in Primorsky region.This region could be divided into 7 areas according to the total indicator of pollution,imbalance of zinc,iron,cobalt,manganese areas,excess of lead,strontium,nickel,chromium areas which could also lead to iodine deficiency.Conclusions Thyroid diseases are environmental-related diseases due to iodine deficiency,further associated with combined imbalance of trace elements and toxic elements.

关 键 词：碘 缺乏症 生态卫生分析 甲状腺功能 毒性元素 必需元素 

分 类 号：R581[医药卫生—内分泌]