CT引导下^(125)I粒子植入治疗腹膜后淋巴结转移癌18例的初步疗效  

The efficacy of CT-guided radioactive ^(125)I seed implantation for retroperitoneal lymph node metastases:preliminary evaluation of 18 cases

作　　者：王娟[1] 吴娟[2] 魏东[3] 隋爱霞[1] 阎晓路[1] 赵静[1] 张宏涛[1] 王泽阳[1] 

机构地区：[1]河北省人民医院肿瘤一科,石家庄050051 [2]河北医科大学 [3]河北省人民医院泌尿外科

出　　处：《介入放射学杂志》2015年第3期219-222,共4页Journal of Interventional Radiology

摘　　要：目的探讨CT引导下125I放射性粒子植入治疗腹膜后淋巴结转移癌的初步疗效。方法回顾性分析接受125I粒子植入治疗的18例腹膜后淋巴结转移癌患者共20个病灶,应用近距离治疗计划系统(TPS)制定治疗计划,粒子活度1.11×107~2.96×107Bq(0.3~0.8 m Ci),处方剂量60~110 Gy,CT引导下经皮、经肝植入粒子,术后验证D90(90%靶体积接受的剂量)53~107 Gy,评价患者临床受益反应(CBR)、2个月局部控制率、1年生存率,观察并发症情况。结果随访时间2~15个月,中位时间5个月;1年生存率22.2%。临床受益率72.2%,有效率70%,2个月局部控制率90%;所有患者均未出现严重并发症。结论 CT引导下125I粒子植入治疗腹膜后淋巴结转移癌近期疗效好,创伤小、并发症少,是一种相对安全的治疗方法。Objective To explore the clinical efficacy of CT-Guided radioactive^125 I seed implantation in treating retroperitoneal lymph node metastases.Methods Eighteen patients with retroperitoneal lymph node metastases（20 lesions in total） received CT-guided radioactive^125 I seed implantation.Treatment planning system（TPS） was used to formulate the therapeutic protocol.The radioactive activity of^125 I particle ranged from 1.11 × 10^7-2.96 × 10^7Bq（0.3-0.8 m Ci） and the matched peripheral dose（MPD） was 60-100 Gy.Postoperative dosimetry was routinely performed for all the patients in one week.Postoperative D90（90%dose received by target volume） was 53-10^7 Gy.The patient＇s clinical benefit response（CBR）,two-month local tumor control rate and one-year survival rate were evaluated,and the complications were recorded.Results All the patients were followed up for 2-15 months with a median time of 5 months.The one-year survival rate was 22.2%.The clinical benefit rate,overall effective rate and two-month local tumor control rate were 72.2%,70.0% and 90.0% respectively.No serious complications occurred in all patients.Conclusion For the treatment of retroperitoneal lymph node metastases,CT-guided radioactive^125 I seed implantation is mini-invasive with satisfactory short-term effect and fewer complications.Therefore,this technique is a relatively safe therapeutic means.

关 键 词：腹膜后淋巴结转移癌 ^125I粒子植入 近距离放射治疗 

分 类 号：R735.4[医药卫生—肿瘤]