中国西部人群PARP-1基因SNP位点多态性与胰腺癌易感性的关系  

The association between PARP-1 Val762Ala polymorphisms and its susceptibility to pancreatic cancer in Chinese Han population in west area

作　　者：李汛[1] 张奇煜[1] 严俊[1] 何雯婷[1] 周文策[1] 张磊[1] 孟文勃[1] 白仲添[1] 朱克祥[1] 朱晓亮[1] 

机构地区：[1]兰州大学第一医院普外二科.甘肃省肝胆胰外科研究所,甘肃兰州730000

出　　处：《西部医学》2015年第4期490-492,共3页Medical Journal of West China

基　　金：中央高校科研专项资金重点项目(lzujbky-2013-k21);甘肃省科技计划项目(0805TCYA040)

摘　　要：目的探讨聚腺苷酸二磷酸核糖转移酶-1（PARP-1）Val762Ala（T2444C）基因多态性与中国西部甘肃省人群胰腺癌易感性的关系,筛查预测胰腺癌的分子标记。方法选取85例良性胰腺疾病患者（对照组）与66例胰腺癌患者（胰腺癌组）,用基质辅助激光解吸电离飞行时间（MALDI-TOF）质谱技术对SNP基因位点进行基因分型,采用χ2-test比较分类变量和各SNP基因分型在病例组和对照组中的分布差异,评价各基因型与胰腺癌发病风险的关系。结果PARP-1 2444C等位基因型（TC＋CC）胰腺癌组明显高于良性对照组,TC＋CC基因型携带者患胆管癌的风险是TT基因型者的3.4倍（OR 3.377,95%CI：1.715-6.646,P〈0.001）。结论本组数据显示PARP-1 Val762Ala（T2444C）单核苷酸多态性与胆管癌易感性相关,C等位基因型携带者患胰腺癌风险相对较高,PARP-1 Val762Ala（T2444C）单核苷酸多态性可作为预测胰腺癌的生物标志物。Objective To investigate the association between the PARP-1 Va1762Ala （T2444C） polymorphism and susceptibility to pancreatic cancer in Chinese Han population in area of Gansu Province and explore molecular markers to predict pancreatic cancer. Methods The PARP-1 Va1762Ala （T2444C） polymorphism was analyzed in 66 cases with pancreatic cancer and 85 controls with benign pancreatic diseases by using the matrix-assisted laser desorption/ionization- time of flight mass spectrometry （MALDI-TOF） method. The genotypes of each SNP site were compared between cases and controls by the chi-square test, to evaluate the association between PARP-1 2444 T/C and susceptibility to pancreatic cancer. Results PARP-1 2444 TC genotypes were overrepresented in pancreatic cancer patients compared with controls （OR 2. 476, 95%CI： 1. 159-5. 292, P=0. 018）. PARP-1 2444 CC genotype were overrepresented in pancreatic cancer patients compared with controls（OR 5. 778, 95%CI： 2. 278-14. 657, P〈0. 001）. Subjects carrying PARP-1 2444 CT/ CC genotypes had a 3.4 fold increased risk for pancreatic cancer compared with TT genotype carriers （OR 3. 377, 95 % CI： 1. 715-6. 646, P〈0. 001）. Conclusion PARP-1 Va1762Ala （T2444C） polymorphism is related to higher risk of pancreatic cancer, which increases the susceptibility to pancreatic cancer.

关 键 词：胰腺癌 聚腺苷二磷酸核糖聚合酶-1 单核甘酸多态性 肿瘤易感性 

分 类 号：R735.2[医药卫生—肿瘤]