T-钙粘附素在肿瘤发生发展中的作用  

Effects of T-cadherin on Tumorigenesis and Tumor Development

作　　者：操龙斌 李继霞[1] 周克元[1,2] 

机构地区：[1]广东医学院生物化学和分子生物学研究所,广东东莞523808 [2]广东医学院广东省医学分子诊断重点实验室,广东东莞523808

出　　处：《中国生物化学与分子生物学报》2015年第3期232-238,共7页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.81272434;No.81201710);广东省自然基金(No.S2012010008259);广东医学院建博科技创新团队项目(No.STIF201105)~~

摘　　要：T-钙粘附素是钙粘附素家族中的一个特殊成员,缺乏跨膜区和胞浆区,是通过糖基磷脂酰肌醇附着于细胞膜上.T-钙粘附素的异常表达参与到多种肿瘤的发生发展过程中,如肿瘤细胞的凋亡、增殖、侵袭和转移等过程.T-钙粘附素还可能参与肿瘤新生血管的形成和胞内外的信号传导过程.本文就T-钙粘附素在肿瘤发生发展过程中的作用及分子机制作一综述,该蛋白有可能成为肿瘤治疗的新靶点.T-cadherin is a special member of the cadherin family, which is absent of the transmembrane and cytoplasmic domain and is anchored to the exterior surface of the plasma membrane through glyeosylphosphatidylinositol （GPI）. Down-regulation of T-cadherin was suggested to associated with the occurrence and development of various tumors, affecting the processed of cell proliferation, apoptosis, invasion and metastasis. In addition, T-cadherin was also found to be involved in the angiogenesis within tumors depending on extraeellular signals, which suggested that T-cadherin might be a potential factor to be considered for cancer therapy. We reviewed the functional studies on T-cadherin in connection with tumor development.

关 键 词：T-钙粘附素 肿瘤 分子机制 

分 类 号：R73-3[医药卫生—肿瘤]