缺血性脑卒中后抑郁患者的BDNF及CRH研究  

A study of BDNF and CRH in patients with post ischemic stroke depression

作　　者：穆夏黎 黄永璐[1] 高宗良[1] 骆鹏飞[1] 

机构地区：[1]安徽医科大学第二附属医院神经内科,合肥230601

出　　处：《安徽医科大学学报》2015年第3期389-392,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81000534)

摘　　要：对30例未发生缺血性脑卒中后抑郁(非PSD组)患者及25例PSD组患者于多个时间点行血清脑源性神经生长因子(BDNF)及促肾上腺皮质激素释放激(CRH)检测。对照组为25例健康成年者。组内比较,PSD组血清BDNF及CRH的变化晚于非PSD组。组间比较,PSD组BDNF各个时间点均显著低于非PSD组,CRH各时间点均显著高于非PSD组。相关性分析显示,PSD组患者治疗前,BDNF与CRH呈负相关性。BDNF及CRH参与了PSD的发生发展,并且两者具有相互作用关系,动态检测血清BDNF及CRH浓度有可能成为预测PSD发生、指导其治疗的生物学指标。The stroke patients were divided into PSD group（n=25） and non-PSD group（n=30）. The brain de-rived neurophic factor （ BDNF） and corticotropin releasing hormone （ CRH） in all groups were detected at several time points. Compared with the non-PSD group, the PSD group had a significantly higher Serum BDNF and a sig-nificantly lower serum CRH. Correlation analysis showed that BDNF and CRH were negatively correlated in PSD patients before treatment. BDNF and CRH was involved in the development of PSD, both had the interaction rela-tions, dynamic detection of serum BDNF and CRH concentration could predict PSD and guide its treatment.

关 键 词：卒中后抑郁 脑源性神经生长因子 促肾上腺皮质激素释放激素 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R749.42[医药卫生—临床医学]