应用三维光学相干断层成像术测量正常人脉络膜厚度及其影响因素的研究  

Assessment of choroidal thickness in healthy eyes using deep range imaging optical coherence tomography

作　　者：张春巍[1] 高效曼[1] 李睿姝[1] 刘玲华[1] 

机构地区：[1]哈尔滨医科大学附属第一医院眼科,黑龙江省哈尔滨市150001

出　　处：《眼科新进展》2015年第3期274-276,共3页Recent Advances in Ophthalmology

基　　金：黑龙江省教育厅科学技术研究项目(编号:12511311)~~

摘　　要：目的应用三维光学相干断层成像术测量正常人脉络膜厚度,并分析其相关影响因素。方法应用三维光学相干断层成像术对67位(106眼)正常人进行后极部脉络膜厚度的测量,软件自动测量并获得脉络膜厚度值。采用单变量和多变量回归分析脉络膜厚度与年龄、性别、眼轴长度、收缩期眼灌注压、舒张期眼灌注压、中央角膜厚度及眼压的关系。结果正常人眼脉络膜厚度为(179.9±36.1)μm。脉络膜厚度随着年龄的增加和眼轴的延长而变薄,呈高度线性负相关性(均为P<0.05),多变量回归分析结果显示,年龄每增加10 a,脉络膜厚度平均下降8.62μm,而眼轴长度每增加1 mm,脉络膜厚度平均下降12.70μm。脉络膜厚度与性别、中央角膜厚度等因素无相关关系。结论DRI OCT可定量检测正常人脉络膜厚度;正常人的脉络膜厚度与年龄和眼轴长度呈负相关。Objective To evaluate the choroidal thickness（ CT） and its relationship with age and axial length in healthy eyes using deep range imaging optical coherence tomography（ DRI-OCT）. Methods A total of 106 eyes of 67 healthy subjects were enrolled in this study.CT was assessed by DRI-OCT. The association between CT and potential confounding variables including age, gender, axial length, intraocular pressure, central corneal thickness and ocular perfusion pressure was examined using univariable and multivariable regression analyses. Results Overall CT was（ 179. 9±36. 1） μm in healthy eyes. Older age and longer axial length was significantly associated with CT（ all P〈0. 05）. Each decade of increasing age was associated with a 8.62 μm decrease in CT and each 1 mm longer axial length,a 12. 70 μm decrease in CT in healthy eyes. CT was not associated with central corneal thickness and gender. Conclusion Normal CT can be accurately measured by DRI-OCT. Older age and longer axial length are associated with thinner CT.

关 键 词：脉络膜厚度 三维光学相干断层成像术 年龄 眼轴长度 

分 类 号：R775[医药卫生—眼科]