磁共振多参数成像技术对乳腺癌诊断效能评价  

The diagnostic efficiency of multi-parameter magnetic resonance imaging in breast cancer

作　　者：何永胜[1,2] 刘斌[1] 潘少辉[2] 杨宏楷[2] 刘志[3] 

机构地区：[1]安徽医科大学第一附属医院放射科,安徽合肥230022 [2]安徽省马鞍山市人民医院影像科 [3]安徽省马鞍山市人民医院病理科

出　　处：《实用放射学杂志》2015年第3期388-392,共5页Journal of Practical Radiology

基　　金：安徽省马鞍山市科技计划项目（2012-Y-01）。

摘　　要：目的：探讨 MRI常规成像、动态增强扫描以及扩散加权扫描多参数成像对乳腺癌的诊断效能。方法分析43例乳腺恶性病变及54个良性病变的 MRI常规检查（形态、边界、边缘及内部强化方式）、动态增强扫描（1 min、2 min、3 min早期强化率及TIC曲线）以及DWI（b=500、800 s/mm22组）结果,以病理结果为“金标准”,分别得出灵敏度、特异度、准确度、阳性预测值、阴性预测值及Kappa值,并对各种参数及方法进行Logistic回归分析。结果边缘（毛刺征）的特异性为96.3%,TIC曲线、ADC值（b=500、800 s/mm2）的灵敏度、特异度分别为97.67%、83.33%,81.4%、90.74%,88.37%、92.59%。边缘（毛刺征）及ADC值（b=800 s/mm2）在良恶性病变的诊断差异有统计学意义（P＜0.05）,TIC曲线在良恶性病变的诊断差异有显著统计学意义（P＜0.01）。结论边缘（毛刺征）、TIC曲线、ADC值（b=800 s/mm2）在乳腺良恶性病变诊断中具有良好的诊断效能。Objective To evaluate the diagnostic efficiency of multi-parameter magnetic resonance imaging of routine MRI,including dynamic contrast-enhanced MRI（DCE-MRI）and diffusion weighed imaging（DWI）in diagnosis of breast cancer.Methods The results of routine MRI （morphology,boundary and,edge and Internal enhancement）,DCE-MRI （1,2,3 minutes early enhanced rate and TIC curve）and DWI （b=500,800 s/mm2 ）were analyzed in 43 cases of malignant breast lesions and 54 benign lesions,with pathology results as＆quot;the gold standard＆quot;,the sensitivity,specificity,accuracy,positive predictive value,negative predictive value and Kappa value had been respectively gained,and Logistic regression analysis were used for statistical analysis.Results The specificity of edge （burr sign） was 96.3%,the sensitivity and specificity of TIC curve,ADC values （b=500,800 s/mm2 ）were respectively 97.67%,83.33%,81.4%, 90.74%,88.37%,92.59%.Edge （burr sign）and ADC values （b=800 s/mm2 ）had a statistic difference in the diagnosis of benign and malignant lesions （P〈0.05）,TIC curve had a significant statistic difference （P〈0.01）.Conclusion Edge （burr sign）,TIC curve,ADC values （b=800 s/mm2 ）had excellent diagnostic efficiency in the diagnosis of benign and malignant lesions.

关 键 词：乳腺癌 磁共振成像 扩散加权成像 动态增强 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]