对细胞信号转导与五脏应时研究相关性的思考  

Thinking about the correlation between cell signal transduction and experimental study on the theory of five internal organs responding to the season

作　　者：杨宗纯 郭霞珍[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中华中医药杂志》2015年第4期974-976,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重点基础研究发展计划(973计划)项目(No.2009CB522706);北京中医药薪火传承"3+3"工程建设项目~~

摘　　要：文章从"五脏应时"的实验研究成果出发,总结了实验提出的科学假说,并就实验方法的选择进行了探讨。细胞信号转导研究的中心问题是细胞感受、转导环境刺激及调节代谢生理反应和基因表达的分子途径,其通过这种方式沟通机体内外环境,跟中医"时脏"理论存在某种共性,因此,从这角度阐述细胞信号转导与中医"时脏"理论的相似性、协调性,及将其引入中医实验的可行性。通过细胞信号转导的研究验证了"时脏"理论的科学内涵,最后提示中医学的研究需要借鉴,在求同存异中谋发展。Based on the experimental results of the theory of five internal organs responding to the season,this paper summarized the scientific hypotheses and discussed the option of experimental methods.The central issues of signal transduction were cell feelings,transducting stimulation of environment,adjusting metabolic physiological reaction and molecular pathways of gene expression,where body realized the communication between internal and external environment.This way had similarity with TCM＇s theory of five internal organs responding to the season.So,it discussed the similarity and coordination between the signal transduction and the theory ‘five internal organs responding to the season＇,and feasibility of introducing signal transduction into the TCM＇s experiments.The scientific implication of the theory of five internal organs responding to the season was verified by the experiments.Finally,it suggested that TCM experiments should take references to seek common points while reserving difference.

关 键 词：五脏应时 细胞信号转导 阴阳 脏象 肾应冬 

分 类 号：R223[医药卫生—中医基础理论]