内质网应激与肿瘤细胞凋亡研究进展  

Research progress of tumor cell apoptosis and endoplasmic reticulum stress

作　　者：吴芳[1] 安永康[2] 朱艳琴[1] 

机构地区：[1]河南中医学院基础医学院,河南郑州450008 [2]河南中医学院第一附属医院,河南郑州450008

出　　处：《现代肿瘤医学》2014年第9期2228-2231,共4页Journal of Modern Oncology

基　　金：河南省科技攻关项目(编号:112102310145;0611043200);郑州市创新科技项目(编号:121PCXTD520)

摘　　要：内质网应激介导的细胞凋亡是一种新的凋亡途径,与死亡受体途径和线粒体途径不同。内质网应激是一种高度保守的细胞反应机制,适度的内质网应激对细胞有保护作用,而过度的内质网应激诱导细胞凋亡。内质网应激与肿瘤的发生、发展及其治疗等关系密切。本文主要介绍内质网应激与肿瘤细胞凋亡的研究进展,为肿瘤治疗研究提供新方向。Apoptosis mediated by endoplasmic reticulum stress is a new pathway of apoptosis,which is different from the death receptor pathway and mitochondrial pathway.Endoplasmic reticulum stress is a highly conserved cellular re-action mechanism,moderate endoplasmic reticulum stress has protective effects on the cells,and excessive ER stress inducing cell apoptosis.There is close relationship between endoplasmic reticulum stress and tumor occurrence,devel-opment and treatment.This paper mainly introduced the research progress of endoplasmic reticulum stress and apopto-sis of tumor cells,providing a new direction for the research of tumor therapy.

关 键 词：内质网应激 细胞凋亡 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]