胱抑素C和C反应蛋白与短暂性脑缺血发作及颅内动脉粥样硬化的关系  

Relationship between cystatin C or C-reactive protein and intracranial atherosclerosis or transient ischemic attack

作　　者：苗成[1] 高绚照[1] 张建璞[1] 彭保成[1] 李红云[1] 马连萍[1] 

机构地区：[1]新乡市中心医院神经内三科,河南新乡453000

出　　处：《新乡医学院学报》2015年第4期350-352,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨胱抑素C(Cys C)和C反应蛋白(CRP)与短暂性脑缺血发作(TIA)及颅内动脉粥样硬化的关系。方法选取新乡市中心医院2012年1月至2014年1月收治的82例TIA患者为观察组,观察组患者进行颅内多层螺旋CT血管成像检查,根据是否发生颅内动脉粥样硬化将82例患者分为动脉粥样硬化组47例和非动脉粥样硬化组35例,并根据是否发生颅内动脉狭窄分为动脉狭窄组50例和非动脉狭窄组32例。另选取同期健康体检健康者82例作为对照组。采用免疫比浊法检测血清Cys C和CRP水平,比较各组受试者血清Cys C和CRP水平。结果观察组患者血清Cys C和CRP水平显著高于对照组(P<0.01),动脉粥样硬化组患者血清Cys C和CRP水平显著高于非动脉粥样硬化组(P<0.05,P<0.01),动脉狭窄组患者血清Cys C和CRP水平显著高于非动脉狭窄组(P<0.05,P<0.01)。结论 Cys C和CRP与TIA的发生有关,血清Cys C和CRP水平对评估TIA患者颅内动脉粥样硬化有重要作用。Objective To study the relationship between cystatin C（ Cys C） or C-reactive protein（ CRP） and transient ischemic attack（ TIA） or intracranial atherosclerosis. Methods Eighty-two patients with TIA were selected from January 2012 to January 2014 in the Central Hospital of Xinxiang City as observation group,all the patients were performed with intracranial multi-slice spiral CT angiography. Eighty-two patients were divided into atherosclerosis group（ n = 47） and non-atherosclerosis group（ n = 35） according to whether the patients had intracranial atherosclerosis;moreover the patients were divided into arteriostenosis group（ n = 50） and non-arteriostenosis group（ n = 32） according to whether the patients had intracranial arteriostenosis. Eighty-two healthy people were selected as control group in the same time. The levels of serum Cys C and CRP were detected by immunoturbidimetry,then the results were compared in the groups. Results The levels of serum Cys C and CRP in observation group were significantly higher than those in control group（ P 0. 01）. The levels of serum Cys C and CRP in atherosclerosis group were significantly higher than those in non-atherosclerosis group（ P 0. 05,P 0. 01）. The levels of serum Cys C and CRP in arteriostenosis group were significantly higher than those in non-arteriostenosis group（ P 0. 05,P 0. 01）.Conclusion Cys C and CRP are related to the occurrence of TIA,serum Cys C and CRP levels were important to evaluating intracranial atherosclerosis in patients with TIA.

关 键 词：胱抑素C C反应蛋白 短暂性脑缺血发作 动脉粥样硬化 

分 类 号：R743.31[医药卫生—神经病学与精神病学]