Cys C、β_2-MG、RBP、MAU在肿瘤患者化疗后早期肾损伤中的临床意义  

The Diagnostic Significance of Cystatin C,β_2-microglobin,Retinol Binding Protein and Microalbuminuria in Detection of Early Renal Damage in Thermotherapy for Patients with Cancer

作　　者：喻靓[1,2] 张煜[1,2] 卢仁泉[1,2] 郭林[1,2] 

机构地区：[1]复旦大学附属肿瘤医院 [2]复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中国肿瘤》2015年第4期340-343,共4页China Cancer

摘　　要：[目的]探讨恶性肿瘤患者化疗后早期肾损伤敏感指标的临床应用。[方法]分别检测恶性肿瘤患者化疗前及化疗后血清半胱氨酸蛋白酶抑制剂C(cystatin C,Cys C)、β2-微球蛋白(β2-microglobin,β2-MG)、视黄醇结合蛋白(retinol binding protein,RBP)、肌酐(CRE)、尿素氮(BUN)以及尿微量白蛋白(microalbuminuria,MAU)、尿肌酐(Cr)水平。[结果]血Cys C在第2次化疗后明显升高﹙P<0.05),血β2-MG、RBP、BUN、CRE及MAU/Cr值在患者2次化疗后均无显著变化﹙P>0.05)。第2次化疗后,血Cys C单独检测阳性率为20%,联合血β2-MG检测阳性率为40%。按化疗方案分组,含顺铂(DDP)组血Cys C在第2次化疗后明显升高﹙P<0.05),而非DDP组2次化疗后均无明显变化﹙P>0.05)。[结论]血Cys C在诊断化疗后肾脏早期损伤时优于常规肾功能指标,尤其适用于化疗方案含DDP患者早期肾损伤的监测。[Purpose] To investigate the application of markers of renal function damage in cancer patients after chemotherapy. [Methods] Serum level of Cystatin C（Cys C）,β2-microglobin（β2-MG）,retinol binding protein（RBP）,blood Urea（BUN）,Creatinine（CRE） and Microalbuminuria（MAU） were detected in patients with cancer at baseline and several days after chemotherapy respectively. [Results] Serum level of Cys C increased significantly after the second cycle of chemotherapy（P〈0.05）.The levels of β2-MG,RBP,MAU,BUN and CRE had no significant differences after two cycles of chemotherapy（P〉0.05）. After the second cycle of chemotherapy,the positive rate of Cys C was 20%,but it of combined determination of Cys C and β2-MG was 40%. Grouped by chemotherapy,the level of Cys C increased significantly after the second cycle of chemotherapy in cancer patients received cisplatin（DDP）-containing protocols（P〈0.05）,but no significant differences for those receiving noncisplatin-containing ones（P〉0.05）. [Conclusions] Detecting the levels of Cys C has a higher valuation in early diagnosing renal function damage. Especially,it is appropriate for cancer patients treated with combined chemotherapy with DDP.

关 键 词：化疗 肾损伤 半胱氨酸蛋白酶抑制剂C β2-微球蛋白 视黄醇结合蛋白 尿微量白蛋白 顺铂 

分 类 号：R730.43[医药卫生—肿瘤]