人乳头瘤病毒感染在鼻内翻性乳头状瘤中的表达及临床意义  

Expression and Clinical Significance of Human Papillomavirus Infection in Nasal Inverted Papilloma

作　　者：计早 韩佳利[1] 阎艾慧[1] 

机构地区：[1]中国医科大学附属第一医院耳鼻咽喉科,沈阳110001

出　　处：《中国医科大学学报》2015年第4期323-326,共4页Journal of China Medical University

基　　金：辽宁省自然科学基金(2014020108-102)

摘　　要：目的探讨人乳头瘤病毒(HPV)感染在鼻内翻性乳头状瘤(NIP)中的表达及意义,为临床治疗提供可靠的科学依据。方法应用聚合酶链式反应(PCR)技术对54例原发组、26例复发组及24例恶变组NIP标本进行HPV 11、16及18检测分析。结果恶变组高危型HPV感染率明显高于原发组和复发组(P<0.01),复发组高危型HPV感染率明显高于原发组(P<0.05);原发组和复发组中,高危型HPV感染者多数存在局部上皮中重度异型增生或局部细胞增生活跃;发生于鼻腔外侧壁组高危型HPV感染率均高于上颌窦、筛窦及额窦组(P<0.05)。结论检测高危型HPV16/18在NIP中的表达状况对NIP的治疗及判断复发和恶变可能具有重要的临床应用价值。Objective To investigate the expression and significance of human papillomavirus（HPV）infection in nasal inverted papilloma（NIP）,and provide reliable scientific basis for the clinical treatment.MethodsPolymerase chain reaction（PCR）technique was adopted to detectHPV 11,HPV 16 and HPV 18 in NIP samples in the primary group（n = 54）,the recurrent group（n = 26）and the malignant group（n = 24）.ResultsThe high- risk HPV infection rate was significantly higher in the malignant group than in the primary group and the recurrent group（P〈0.01）. The high-risk HPV infection rate was significantly higher in the recurrent group than in the primary group（P〈0.05）. In the primary groupand the recurrent group,most patients with high-risk HPV infection had local moderate to severe epithelial hyperplasia or active hyperplasia of localcells. The infection rate of high-risk HPV which occurred in the lateral wall of nasal cavity was higher than that in the maxillary sinus,ethmoid sinusand frontal sinus（P〈0.05）.ConclusionThe detection of expression status of high-risk HPV16/18 in NIP may have important clinical applicationvalue for NIP therapy and judgment of recurrence and malignancy.

关 键 词：鼻 内翻乳头状瘤 人乳头瘤病毒 聚合酶链式反应 

分 类 号：R739.62[医药卫生—肿瘤]