高强度聚焦超声消融兔腹主动脉旁肝肿瘤的安全性和有效性  

Safety and effectiveness of high-intensity focused ultrasound ablation for liver tumor adjacent to rabbit abdominal aorta

作　　者：税莲[1] 何敏[1] 刘映江[1] 龚春梅[1] 张炼[1] 

机构地区：[1]重庆医科大学生物医学工程学院、省部共建国家重点实验室培育基地-重庆市超声医学工程重点实验室、重庆市生物医学工程学重点实验室,重庆市400016

出　　处：《中国肿瘤临床》2014年第23期1517-1520,共4页Chinese Journal of Clinical Oncology

基　　金：国家重点基础研究发展计划(编号:2011CB707900);十二五科技支撑计划(编号:2011BAI14B01);重庆市自然科学基金(编号:cstc2013jcyj A10109、cstc2011jj A10033、cstc2012jj A10083)资助~~

摘　　要：目的:观察高强度聚焦超声消融兔腹主动脉旁肝肿瘤后肝肿瘤剂量学、磁共振图像、病理学及生存期影响,评价HIFU消融兔腹主动脉旁肝肿瘤安全性和有效性。方法:分别于HIFU组(32只)和对照组(20只)实验兔建立腹主动脉旁的VX2肝肿瘤模型,HIFU组瘤兔于MR引导的高强度聚焦超声消融肿瘤,分析腹主动脉旁肿瘤消融剂量学,MR观察消融前后肿瘤影像学变化,病理学观察肿瘤消融后坏死情况,对比观察HIFU组与对照组瘤兔生存期。结果:MRI和病理学均表明MR引导下HIFU能完全消融兔腹主动脉旁VX2肝肿瘤,EEF为25.72±11.40 J/mm3HIFU组的生存期明显高于对照组,差异具有统计学意义(P<0.05)。结论:HIFU能安全有效消融兔腹主动脉旁VX2肝肿瘤并且能明显提高存活期。Objective： To evaluate the safety and efficacy of high-intensity focused ultrasound （HIFU） ablation for the VX2 liver tumor near the hepatic main blood vessels of rabbits by using dosimetry and magnetic resonance imaging （MRI） and by analyzing path- ological changes and survival. Methods： Rabbits with VX2 liver tumor adjacent to the abdominal aorta were divided into the HIFU （n= 32） and control groups （n=20）. MRI-guided HIFU was employed for the ablation of the liver tumor in the HIFU group. The ablation vol- ume and the energy efficiency factor （EEF） of the 32 ablated rabbits were further analyzed. MRI and pathology were used to compare the changes in the tumor before and after HIFU. The survival of the animals in the HIFU and control groups was also determined. Re- sults： Both pathology and imaging showed that the rabbit liver VX2 tumor adjacent to the abdominal aorta was completely ablated, with an EEF of （25.72±11.40） J/ram3. The survival rate was significantly higher in the HIFU group than in the control group （P〈0.05）. Conclusion： HIFU ablation is safe and effective in rabbit VX2 liver tumor near the abdominal aorta. This approach significantly in- creases survival.

关 键 词：高强度聚焦超声 兔 腹主动脉 肝脏肿瘤 磁共振 

分 类 号：R735.7[医药卫生—肿瘤]