新制柴连汤治疗单纯疱疹性角膜炎的系统评价与Meta分析  

System evaluation and Meta analysis of Xinzhi Chailian Decoction on herpes simplex keratitis

作　　者：姜雨辰[1] 纪凯[1] 刘桂霞[2] 

机构地区：[1]长春中医药大学,长春130117 [2]长春中医药大学附属医院

出　　处：《中国中医眼科杂志》2014年第6期413-416,共4页China Journal of Chinese Ophthalmology

摘　　要：目的从循证医学的角度系统评价新制柴连汤治疗单纯疱疹性角膜炎的疗效。方法通过全面检索与新制柴连汤相关的随机对照研究文献,进行质量评价,纳入合格文献进行Meta分析。结果 7个随机对照试验(RCT)纳入系统评价,均为Jadad评分量表评分<3分的低质量研究。Meta分析结果显示新制柴连汤联合常规治疗的临床疗效优于单纯使用常规治疗。临床疗效比较OR值为4.86,95%CI为(2.92,7.48)。结论新制柴连汤联合常规治疗用于单纯疱疹性角膜炎可能取得较单一常规治疗更好的效果,但由于纳入的研究方法学质量低,发生偏倚的可能性高,尚需更多设计合理的高质量临床试验加以验证。OBJECTIVE To systematically appraise the effect of Xinzhi Chailian Decoction on herpes sim- plex keratitis. METHODS Randomized controlled trial reports about Xinzhi Chailian Decoction were searched and quality evaluated. And then, these literatures were used to Meta analysis. RESULTS Seven randomized controlled trials, which were poor quality with Jadad scores less than 3, were included in systematic review. A Meta-analysis showed that the combination of Xinzhi Chailian Decoction and conventional treatment had better effectiveness than the regular conventional treatment. The odds ratio （OR） and 95% confidence interval （CI） of comparison were 4.86 （2.92~7.48）. CONCLUSIONS The combination of Xinzhi Chailian Decoction and conventional treatment had bet- ter effectiveness than the regular conventional treatment. Nevertheless, because of the unclear methodological quality of the include studies, the results may possibly be of much bias. Further well-designed clinical studies are required for the evaluation of Xinzhi Chailian Decoction on herpes simplex keratitis.

关 键 词：单纯疱疹性角膜炎 新制柴连汤 系统评价 META分析 

分 类 号：R772.2[医药卫生—眼科] R276.7[医药卫生—临床医学]