福建地区口腔癌患者p53基因72密码子多态性与口腔癌易感性的研究  

Study on p53 Gene Condon 72 Polymorphisms and Susceptibility of Oral Cancer of Fujian Oral Cancer Patients

作　　者：何保昌[1] 陈法[1] 刘芳萍[1] 柳迪萌 陈珍[1] 蔡琳[1] 

机构地区：[1]福建医科大学公共卫生学院流行病与卫生统计学系,福州350108

出　　处：《福建医科大学学报》2014年第6期372-377,共6页Journal of Fujian Medical University

基　　金：国家级大学生创新创业训练计划项目(201410392020);福建省教育厅科研项目(JA13141);福建医科大学苗圃基金(2010MP019)

摘　　要：目的研究p53基因多态性与口腔癌的关联。方法对149例口腔癌病例和303例对照病例采集5mL血液样本,提取基因组DNA,采用PCR-RFLP法检测p53基因的多态性,利用Stata12.1软件分析p53基因的多态性与口腔癌的关联,并进行基因-环境交互作用分析。结果 p53基因Pro/Pro基因型携带者较Arg/Arg基因型携带者口腔癌的发病风险增加1.837倍(95%CI:1.016,3.325)。p53基因Pro/Pro基因型与饮酒有相乘交互作用(OR相乘:4.375,95%CI:1.646,11.627)。结论 p53基因Pro/Pro基因型可能是福建地区口腔癌的易感基因,Pro/Pro基因型与饮酒具有相乘交互作用。Objective To discover the association between p53 gene polymorphism and oral cancer in Fujian area . Methods 5 mL blood sample of 149 oral cancer patients and 303 controls w ere collected and their DNAs were extracted . p53 gene polymorphism was detected by polymerase chain reaction‐re‐striction fragment length . The association between p53 gene polymorphism and oral cancer ,and the in‐teraction effects of p53 gene polymorphism and environmental factors were analyzed by using Stata12 .1 . ResuIts Compared with Arg/Arg genotype ,p53 gene with Pro/Pro genotype was associated with higher risk of oral cancer（OR：1 .837 ,95% CI：1 .016 ,3 .325） . A multiplicative interaction between p53 gene with Pro/Pro genotype and alcohol drinking was found for oral cancer （ORmultiplicative ：4 .375 ,95% CI：1 .646 , 11 .627） . ConcIusions There is multiplication interaction between p53 gene with Pro/Pro genotype and alcohol drinking ,w hich may be related to susceptibility of oral cancer in Fujian area .

关 键 词：口腔肿瘤 基因 p53 多态性 限制性片段长度 

分 类 号：R739.85[医药卫生—肿瘤]