S-腺苷蛋氨酸联合血栓通治疗胆汁淤积性肝炎的临床疗效  

Effect of S-adenosyl methionine combined with Xueshuantong in treatment of cholestatic hepatitis patients

作　　者：李儒贵[1] 谭华炳[1] 李芳[1] 李刚[1] 郭鹏[1] 张薇薇[1] 占国清[1] 

机构地区：[1]湖北医药学院附属人民医院感染性疾病科,湖北十堰442000

出　　处：《胃肠病学和肝病学杂志》2015年第3期348-350,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的评估S-腺苷蛋氨酸联合血栓通治疗胆汁淤积性肝炎的效果及不良反应。方法 54例胆汁淤积性肝炎患者被随机分为治疗组(30例)和对照组(24例)。两组均予常规保肝治疗。对照组给予S-腺苷蛋氨酸针剂1.0 g/d静脉滴注;治疗组在对照组基础上加用血栓通针剂0.5 g/d静脉滴注,疗程均为4周。比较两组治疗前后症状、生化指标(ALT、TBil、γ-GT、ALP、TBA)变化及不良反应。结果治疗组治疗后TBil、γ-GT、ALP及TBA下降程度高于对照组(P<0.05);其皮肤瘙痒和灰白便的改善也优于对照组(P<0.05);治疗组总有效率为83.3%,高于对照组的58.3%(P<0.05)。两组患者耐受性良好,无严重不良反应发生。结论S-腺苷蛋氨酸联合血栓通治疗胆汁淤积性肝炎效果理想,副作用小,值得临床推广。Objective To evaluate the effect and adverse reactions of S-adenosyl methionine combined with Xue- shuantong in treatment of cholestatic hepatitis patients. Methods Fifty-four patients with cholestasis hepatitis were ran- domly divided into treatment group （30 cases） and control group （24 cases）. Two groups were given conventional treat- ment, the control group was intravenously injected with S-adenosyl methionine injection 1.0 g/d, while the treatment group was treated with Xueshuantong injection 0.5 g/d besides the above medicines. The regimen lasted for four weeks. Clinical symptoms, biochemical indexes （ALT, TBil, γ-GT, ALP, TBA） and adverse reaction of the two groups were compared before and after treatment. Results After treatment, TBil, γ-GT, ALP and TBA in the treatment group were decreased significantly than those in the control group （P 〈 0.05 ）. The improvement of skin pruritus and cinereous stool in treatment group were also better than those in control group （P 〈 0.05）. The total effective rate of treatment group was 83.3% , which was higher than 58.3% of control group （P 〈0.05）. The two groups had no serious adverse reac- tions. Conclusion S-adenosyl methionine combined with Xueshuantong has good clinical efficacy and security for the treatment of cholestatic hepatitis patients.

关 键 词：S-腺苷氨酸 血栓通 胆汁淤积性肝炎 疗效 

分 类 号：R575[医药卫生—消化系统]