内质网自噬——疾病防治的新靶标  

Reticulophagy-a new target for diseases prevention and treatment

作　　者：李赫宁[1] 李兰芳[1] 陈临溪[1] 

机构地区：[1]南华大学药物药理研究所,湖南衡阳421001

出　　处：《中国药理学通报》2015年第3期302-308,共7页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81270420;81470434);湖南省自然科学基金省市联合(衡阳)基金重点项目(No12JJ8013);湖南省自然科学基金资助项目(No 14JJ3102);国家博士后基金(No 2014M560647);湖南省"十二五"重点学科建设项目资助

摘　　要：内质网自噬是指内质网功能发生改变时,细胞激活选择性自噬以清除细胞内受损的内质网或内质网片段的过程。其主要的功能是改善细胞内环境,起细胞保护作用。内质网自噬作为选择性自噬研究的新领域,与细胞中其他类型的选择性自噬和细胞凋亡之间关系密切,在疾病发生发展中有重要作用。该文综述了内质网自噬的形成过程,细胞内调控方式,与其他选择性自噬间的相互作用,并阐述了内质网自噬参与糖尿病、神经退行性疾病和肾脏疾病等多种疾病的发生发展,逐步成为疾病防治的新靶标。The cells activate selective autophagy and remove damaged endoplasmic reticulum or fragments in cells when chan- ges the function of endoplasmic reticulum, known as the endo- plasmic reticulum autophagy. Reticulophagy is a selective auto- phagy and can remove damaged endoplasmic reticulum or frag- ments in cells. The function of reticulophagy is to improve the inside environment of ceils and protect the cells. As a new field of selective autophagy research, it and the other types of selec- tive autophagy are closely interconnected. Meanwhile, it is also associated with cell apoptosis and has a very important influence on diseases. The paper reviews the formation of reticulophagy, intraceUular regulation and the interaction between other selective autophagys. In addition, we also describe the close relationship between reticulophagy and some diseases, such as diabetes, neu- rodegenerative diseases and renal diseases. Hence, reticulophagy gradually becomes a new target for disease prevention and treat- ment.

关 键 词：内质网自噬 自噬 未折叠蛋白反应 内质网应激 选择性自噬 药物靶标 

分 类 号：R-05[医药卫生] R329.24