薄荷醇及其受体TRPM8与肿瘤关系研究进展  

Research progress in the role of menthol and its receptor TRPM8 in tumor

作　　者：陈晨[1] 刘兆国[1] 汪思亮[1] 盛晓波[1] 韦忠红[1] 杨召聪[1] 陈文星[1,2,3] 王爱云[1,2,3] 郑仕中[1,2] 江国荣[1] 陆茵[1,2] 

机构地区：[1]南京中医药大学药学院,江苏南京210046 [2]江苏省中药药效与安全性评价重点实验室,江苏南京210046 [3]江苏省中医药防治肿瘤协同创新中心,南京210023

出　　处：《中国药理学通报》2015年第3期312-314,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81173174;81202655);十一五科技支撑计划(No 2008BAI51B02);教育部博士点基金(No 20113237110008);江苏省高校优势学科建设工程资助项目(中药学优势学科资助);2013年江苏高校优秀科技创新团队计划

摘　　要：薄荷是一种被广泛使用的植物药和食品添加剂,其发挥功能的主要成分为薄荷醇。研究发现薄荷醇具有抗炎镇痛、抗菌抗病毒及止咳等多种生理功能。近年来,研究发现薄荷醇具有明显的抗肿瘤活性,能抑制多种恶性肿瘤的生长和演进。然而,也有研究发现使用添加薄荷醇的香烟制品其肺癌发病率明显高于一般烟民。该文对薄荷醇的生理功能及其受体TRPM8进行综述,着重对近年来薄荷醇及其受体与肿瘤关系的研究进展进行综述,并探讨薄荷醇在临床应用的局限性和不良反应,为后续的科学研究及指导临床提供参考。Mint is a widely used plant medicine and food addi-tives, whose main component is menthol. It has been found that menthol has many physiological functions such as anti-inflamma-tion, analgesia, antibacterial and antiviral. In recent years, a number of studies found that menthol had obvious antitumor ac-tivity and could inhibit the growth and evolution of a variety of malignant tumors. However, some studies also found that using menthol cigarettes products could result in significant higher in-cidence of lung cancer than normal smokers. This article mainly reviews the recent progress of physiological functions of menthol and its receptor TRPMS. We highlight the associations between menthol and its receptor TRPM8 with cancers. We also discuss the clinical limitation and adverse reactions of using menthol, which may provide valuable references for follow-up cancer-relat- ed studies.

关 键 词：薄荷醇 TRPM8 抗肿瘤 致癌 临床应用 不良反应 

分 类 号：R-05[医药卫生] R282.71