限制性胎盘嵌合体对产前诊断的影响  

Impact of confined placental mosaicism on prenatal diagnosis

作　　者：周希亚[1] 戚庆炜[1] 郝娜[1] 周京[1] 刘俊涛[1] 边旭明[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院,北京100730

出　　处：《生殖医学杂志》2015年第3期171-176,共6页Journal of Reproductive Medicine

摘　　要：目的探讨限制性胎盘嵌合体(CPM)对产前诊断的影响及产前咨询中存在的问题。方法回顾性分析我院2013年早孕期绒毛活检发现的2例CPM患者的临床资料,结合国内外近年来关于CPM的研究报道,探讨CPM对产前诊断的影响处置方法。结果 2013年,我院行绒毛活检的211例妊娠妇女中,发现2例CPM,发生率为0.9%。2例CPM患者均妊娠至足月,其中1例发生胎儿宫内发育受限,此例患者分娩后经胎盘多点染色体分析,胎盘仍为嵌合状态。2例患者分别因剖宫产史、胎儿宫内窘迫行足月剖宫产,新生儿预后良好。结论 CPM的产前诊断并不困难,但需要良好地咨询及随访,出生后应对胎盘进行细胞遗传学检查。Objective：To explore the clinical significance of confined placental mosaicism（CPM）and its impact on prenatal diagnosis.Methods：The data of four patients with CPM detected by chorionic villus sampling（CVS）and karyotyping at first trimester of pregnancy in Peking Union Medical College Hospital in 2013 were analyzed retrospectively.The prenatal diagnosis and management method were discussed after literature review.Results：Chorionic villus sampling was carried out in 211 pregnant women in Peking Union Medical College Hospital in 2013.Among them,2patients suffered CPM diagnosed by aminiocentesis or cord blood sampling and karyotyping in later gestation,with the incidence of 0.9%.Both pregnancies continued to term delivery.One had fetal intrauterine growth retardation,and placenta mosaicism was confirmed by cytogenetical analysis.Both patients had full-term cesarean section with the delivery of healthy babies.Conclusions：The prenatal diagnosis of CPM is not difficult,but it needs prenatal counseling and surveillance.The placenta should be examined morphologically and cytogenetically.

关 键 词：限制性胎盘嵌合体 绒毛活检 单亲二体 胎儿宫内生长受限 

分 类 号：R[医药卫生]