芬吗通在氯米酚促排卵周期子宫内膜薄患者中的应用  

Application of Femoston for patients with thin endometrium in ovulation induced by clomiphene citrate

作　　者：王海燕 孙林 王磊 李北氢 邵小光 

机构地区：[1]大连市妇女儿童医疗中心生殖医学中心,大连116000

出　　处：《生殖医学杂志》2015年第3期200-203,共4页Journal of Reproductive Medicine

摘　　要：目的观察在枸橼酸氯米酚(CC)促排卵周期中发生子宫内膜薄情况下应用补佳乐和芬吗通对子宫内膜厚度及HCG日雌激素水平的影响。方法56个多囊卵巢综合征(PCOS)患者应用氯米酚促排卵周期中子宫内膜薄,随机分为2组,每组28周期,探讨枸橼酸氯米酚加用补佳乐或芬吗通对子宫内膜厚度和HCG日雌激素水平的变化及妊娠率的影响。结果HCG日雌二醇水平补佳乐组低于芬吗通组,差异有统计学意义(P<0.05)。HCG日内膜厚度补佳乐组低于芬吗通组,统计学上无差异。按内膜厚度分组后,芬吗通组的内膜厚度>8 mm所占比例明显增加,高于补佳乐组,差异有统计学意义(P<0.05)。结论CC促排卵周期中内膜薄者应用芬吗通使内膜增厚效果比补佳乐更好。Objective：To compare the effects of clomiphene citrate（CC）combined with Femoston or estradiol valerate on endometrium thickness and estrogen level in the patients with thin endometrium in ovulation induced by clomiphene citrate.Methods：Fifty six patients with polycystic ovary syndrome（PCOS）and endometrial thin in ovulation induced by CC were randomly divided into two groups：estradiol valerate group and Femoston group,28 cycles for each group.CC combined with Femoston or estradiol valerate was used to test the effect on endometrial thickness and estrogen level.Results：The estradiol（E2）levels on the HCG day in estradiol valerate group were significantly lower than those in Femoston group（P0.05）.The endometrial thickness on HCG day in estradiol valerate group was lower than that in Femoston group,but the difference was not significant（P0.05）.The proportion of endometrial thickness more than 8mm after Femoston group significantly increased compared with estradiol valerate group（P0.05）.Conclusions：Femoston can be used for the patients with thin endometrium in ovulation induced by clomiphene citrate to increase the endometrium thickness.The effect of Femoston is better than that of estradiol valerate.

关 键 词：芬吗通 补佳乐 氯米芬 促排卵 子宫内膜 

分 类 号：R[医药卫生]