苯甲酸阿格列汀有关物质的合成  

Synthesis of Related Substances from Alogliptin Benzoate

作　　者：王萌[1] 何庆国 安丹[1] 姚军[1] 

机构地区：[1]河北科技大学化学与制药工程学院,河北石家庄050018 [2]石家庄智同医药科技有限公司,河北石家庄050011

出　　处：《化学试剂》2015年第4期379-381,共3页Chemical Reagents

摘　　要：苯甲酸阿格列汀为二肽基肽酶抑制剂。为了对苯甲酸阿格列汀产品进行质量控制,以合成路线为基础,制备了4种有关物质,并且通过核磁共振和质谱确定了其化学结构。同时,根据有关物质的结构分析了其可能产生的原因。以此为基础,通过改善实验条件,成功合成出了符合质量标准的苯甲酸阿格列汀。Alogliptin benzoate is one of the dipeptidyl peptidase inhibitors. To control the quality of the alogliptin benzoate, four re- lated substances were prepared based on the synthetic route,and the structures were confirmed by 1HNMR and MS. The reasons leading to the related substances were analysized based on the structures. The alogliptin benzoate that meet the quality standards successfully were synthesized via experimental condition improvement.

关 键 词：苯甲酸阿格列汀 有关物质 合成 

分 类 号：R914.5[医药卫生—药物化学]