术前尿液BLCA-4及IL-8水平与膀胱癌临床病理特征的关系及意义  

The Relationship and Significance of Preoperative Urinary BLCA-4 and IL-8 Levels with Clinical Pathological Character of Bladder Carcinoma

作　　者：杨大富[1] 陆荣森[1] 廖俊[2] 梁华良[1] 黄芳伟[1] 

机构地区：[1]广东省信宜市人民医院泌尿外科,广东信宜525300 [2]中山大学附属第一医院泌尿外科,广东广州510080

出　　处：《河北医学》2015年第6期884-887,共4页Hebei Medicine

基　　金：国家自然科学基金;(编号:81001146;30872584)

摘　　要：目的:探讨术前尿液BLCA-4及IL-8水平与膀胱癌病理特征的关系并确定其在临床诊断上的意义。方法:采用酶联免疫反应原理分别检测膀胱癌组患者、正常对照组和高危性膀胱癌人群中术前尿液中BLCA-4和IL-8水平,分析研究他们与膀胱癌临床病理特征的关系。结果:实验测得BLCA-4水平的Cutoff值为14.0 A/μg.protein,正常对照组尿中BLCA-4含量为2.7±5.8 A/μg.Protein;高危性膀胱癌组BLCA-4含量为9.1±18.7 A/μg.protein,均低于实验的Cut-off值,但高危性膀胱癌组明显高于正常对照组(P<0.01);而膀胱癌组患者尿中BLCA-4含量为45.3±69.2 A/μg.protein;显著高于正常对照组和高危性膀胱癌组(P<0.001)。与正常对照组相比,术前尿液中IL-8水平在高危性膀胱癌组和膀胱癌组均显著性上升,统计学差异分别为P<0.01,P<0.001。膀胱癌组患者术前尿液中BLCA-4和IL-8水平均与年龄、性别、肿瘤单发还是多发,初发还是复发没有显著统计学差异(P均>0.05),而与肿瘤的病理分期和分级有显著统计学差异(P<0.05)。结论:术前尿液BLCA-4及IL-8水平可能成为膀胱癌肿瘤诊断标志物,为临床早期诊断和病理特征判断提供依据。Objective：To explore the relationship of preoperative urinary BLCA-4 and IL-8 levels with clinically pathological characters of bladder cancer and to identify the significance in clinical diagnosis. Method：Enzyme-linked immune-sorbent reaction principle was adopted to detect the levels of preoperative urinary BLCA-4 and IL-8 in patients with bladder carcinoma, healthy controls and high-risk bladder carci- noma populations with aiming to analyze the relationship between the clinical pathological character of blad- der carcinoma and the levels of BLCA-4 and IL-8. Result： The cut-off value of BLCA-4 was 14.0 A/μg. protein. The level of BLCA-4 in healthy controls was 2.7±5.8 A/ixg.protein and high-risk bladder carcino- ma populations 9.1± 18.7 A/μg. protein, both of which were lower than the cut-off value, but the level of BLCA-4 in high-risk bladder carcinoma populations was significantly higher than the healthy controls（P〈0. 01 ） .While the level of BLCA-4 in bladder carcinoma patients was 45.3±69.2 A/μg.protein, which was sig- nificantly higher than the other two groups （ P〈0.001） .And compared to healthy controls, the preoperative u- rinary level of IL-8 in high-risk bladder carcinoma populations and bladder carcinoma patients was signifi- candy elevated （ P〈0.01 and P 〈0. 001 ） respectively. In bladder carcinoma patients, preoperative urinary BLCA-4 and IL-8 levels showed no significant difference in ages, genders, single or multiple tumors, pri- mary or recurrent tumors （ P 〉 0.05 ） , but relatively significant difference in tumor stages and grades （ P 〈 0. 05）.Conclusion： Preoperative urinary BLCA-4 and IL-8 levels can be served as tumor diagnostic markers for indicators for bladder carcinoma and can provide reference for early clinical diagnose and pathological characters judgement.

关 键 词：膀胱癌特异性核基质蛋白-4( BLCA -4) 白细胞介素-8( IL-8) 膀胱癌 病理特征 

分 类 号：R737.14[医药卫生—肿瘤]