大肠癌组织中VEGF、MIF的表达及临床意义  

Expression and significance of VEGF,MIF in colorectal cancer

作　　者：王苗锋[1] 熊茂明[1] 李火友[1] 龙腾云[1] 

机构地区：[1]安徽医科大学第一附属医院普外科,安徽合肥230032

出　　处：《重庆医学》2015年第11期1478-1480,共3页Chongqing medicine

基　　金：安徽省高等学校省级自然科学研究重点项目(KJ2011A155);安徽省卫生厅医学科学研究基金(2010B007)

摘　　要：目的探讨大肠癌组织中血管内皮生长因子(VEGF)及人巨噬细胞游走抑制因子(MIF)的表达及临床意义。方法选取80份经手术切除并经病理证实为大肠癌的组织蜡块(观察组)及80份距癌肿边缘5cm以上经病理证实无癌细胞残存的正常大肠组织(对照组),SP法检测VEGF、MIF在大肠癌及正常大肠组织中的表达。结果VEGF,MIF在观察组中阳性率为77.50%、82.50%,在对照组阳性率为22.50%、27.50%,观察组阳性率明显高于对照组,差异有统计学意义(P<0.05)。VEGF、MIF在大肠癌组织中的表达与肿瘤的浸润深度、淋巴结转移、临床分期相关,与性别、年龄、组织学分化无关。结论 VEGF、MIF在大肠癌组织中高表达。Objective Todetecttheexpressionofvascularendothelialgrowthfactor（VEGF）andmigrationinhibitoryfactor （MIF） in colorectal cancer .Methods The immunohistochemical staining （SP method） was used to measure the expression of VEGF and MIF in 80 samples of colorectal cancer and 80 samples of normal colorectal tissues at 5 cm apart from the tumor edge . The relationship between VEGF and MIF with the clinical pathologic characteristics of colorectal cancer was anlyzed .Results The positive rates of VEGF and MIF in the colorectal cancer tissues were 77 .50% and 82 .50% respectively ,but which in the normal colorectal tissues were 22 .50% and 27 .50% respectively ,the positive rate of VEGF and MIF expression in the colorectal cancer tis‐sues were higher than that in the normal colorectal tissue with statistical difference （P〈0 .05） .The expression of VEGF and MIF had correlation with the tumor infiltration depth ,lymph node metastasis ,and clinical stage ,but no correlation with gender ,age and histodifferentiation .Conclusion VEGF and MIF are highly expressed in the colorectal cancer tissues .

关 键 词：结直肠肿瘤 血管内皮生长因子类 巨噬细胞游走抑制因子 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]