细胞凋亡调控因子-2、p53基因、细胞增殖因子-67、细胞角蛋白-7在腺性膀胱炎与膀胱上皮癌组织中表达的研究  

Research on the expressions of bcl-2,p53,ki-67 and ck-7 in cystitis glandularis and uroepithelium carcinoma tissue

作　　者：颜明根 马小兵[2] 张勇[2] 刘雪梅[2] 

机构地区：[1]解放军第四一一医院分院,上海200083 [2]上海市江湾医院泌尿外科

出　　处：《海军医学杂志》2015年第2期101-103,109,共4页Journal of Navy Medicine

基　　金：上海市虹口区卫生局重点课题(060312)

摘　　要：目的探讨细胞凋亡调控因子-2(bcl-2)、p53基因(p53)、细胞增殖因子-67(ki-67)、细胞角蛋白-7(ck-7)在腺性膀胱炎与膀胱上皮癌组织中表达的相关性。方法用免疫组化法检测46例腺性膀胱炎、21例膀胱上皮癌组织以及11例正常膀胱黏膜组织中bcl-2、p53、ki-67、ck-7的表达情况,并进行相关性分析。结果在膀胱上皮癌、腺性膀胱炎、正常膀胱黏膜组织中,bcl-2表达阳性率分别为4.76%、69.57%、90.91%;p53表达阴性率分别为9.52%、84.78%、81.82%;ki-67表达阴性率分别为23.81%、71.74%、72.73%;ck-7表达阴性率分别为9.52%、21.74%、9.09%。bcl-2在腺性膀胱炎中表达明显低于膀胱上皮癌组织,但明显高于正常膀胱黏膜;p53、Ki-67在腺性膀胱炎中表达明显高于正常膀胱黏膜,但明显低于膀胱上皮癌组织;ck-7在膀胱上皮癌、腺性膀胱炎与正常膀胱黏膜组织中表达差异不明显(P>0.05)。结论 bcl-2、p53、ki-67在腺性膀胱炎的生物转归中占有重要地位,对临床诊断与治疗具有指导意义。Objective To investigate the correlation in the expressions of bcl-2,p53,ki-67 and ck-7 in cystitis glandularis and uroepithelium carcinoma tissue. Methods The expressions of bcl-2,p53,ki-67 and ck-7 in 46 cases of cystitis glandularis,21 cases of uroepithelium carcinom and 11 cases of normal bladder mucosal tissues were assessed by immunohistochemistry and the correlation was statistically analyzed. Results（ 1） The positive expressions of the bcl-2 in normal bladder mucosa,cystitis glandularis and uroepithelium carcinoma were respectively 4. 76%,69. 57% and 90. 91%.（ 2） The negative expressions of p53 in normal bladder mucosa,cystitis glandularis and uroepithelium carcinoma were respectively 9. 52%,84. 78% and 81. 82%.（ 3） The negative expressions of ki-67 in the said tissues were respectively 23. 81%,71. 74% and 72. 73%.（ 4） The negative expressions of ck-7 were respectively 9. 52%,21. 74% and 9. 09%. The negative expression of bcl-2 in cystitis glandularis was significantly lower than that in uroepithelium carcinoma tissue,but was obviously higher than that in normal bladder mucosa. The expressions of p53 and ki-67 in cystitis glandularis were significantly higher than those in normal bladder mucosa,but were obviously lower than those in uroepithelium carcinoma tissue. No significant differences could be noted in the expressions of ck-7 in uroepithelium carcinoma,cystitis glandularis and normal bladder mucosa. Conclusion Research results indicated that the expressions of bcl-2,p53 and ki-67 played an important role in the regression of cystitis glandularis,and seemed to have great importance in clinical diagnosis and treatment of cystitis glandularis.

关 键 词：膀胱上皮癌 腺性膀胱炎 细胞凋亡调控因子-2 P53基因 细胞增殖因子-67 细胞角蛋白-7 

分 类 号：R737[医药卫生—肿瘤]