铁代谢与神经变性性疾病  

Iron metabolism and neurodegenerative disease

作　　者：方明娟[1] 杨任民[2] 吴君霞[2] 程楠[2] 

机构地区：[1]安徽中医药大学研究生部,合肥230038 [2]安徽中医药大学神经病学研究所附属医院神经内科,合肥230061

出　　处：《中华临床医师杂志（电子版）》2015年第7期101-104,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：铁是中枢神经系统必不可少的,脑铁代谢异常主要是由于其蛋白功能的异常或表达失控,异常的脑铁代谢可导致神经变性性疾病患者神经元死亡。本文就肝豆状核变性、多发性硬化、肌萎缩侧索硬化、不宁腿综合征等神经变性性疾病的发病机制与脑铁代谢异常的关系做一综述。Iron is essential for central nervous system. Abnormalities in iron metabolism may lead by the disrupted expression or function of iron metabolism proteins induced. It may lead to neuronal death in patients with neurodegenerative disease. In this article, we reviewed the relationship between brain iron dysregulation and the development or pathogenesis of some neurodegenerative diseases, such as hepatolenticular degeneration, multiple sclerosis, amyotrophic lateral sclerosis, and restless leg syndrome.

关 键 词：肝豆状核变性 多发性硬化 肌萎缩侧索硬化 不宁腿综合征 铁代谢 

分 类 号：R741[医药卫生—神经病学与精神病学]