解脲支原体与人乳头瘤病毒感染相关性研究  

Correlation between ureaplasma urealyticum and human papilloma virus infection

作　　者：李国玉[1] 池细弟[1] 高世华[1] 

机构地区：[1]福建医科大学附属南平市第一医院检验科,福建南平353400

出　　处：《国际检验医学杂志》2015年第7期950-951,953,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨解脲支原体(UU)感染与人乳头瘤病毒(HPV)感染相关性。方法回顾性分析348例来本院妇产科就诊患者,采集宫颈分泌物标本,使用荧光定量PCRABI7300检测仪,对该标同时检测人乳头瘤病毒DNA常见高危型(16、18、31、33、45、52、56、58)及解脲支原体DNA,设置两组数据,第一组以UU DNA阳性为实验组,UU DNA阴性为对照组,对两组数据进行常见高危型HPV DNA检出阳性率进行分析。第二组数据以UU DNA拷贝数大于104为阳性对照,以UU DNA拷贝数小于104为阴性对照,两组数据进行常见高危型HPV DNA检出阳性率进行分析。结果第一组数据UU DNA检出率达到67.5%(235/348),UU阳性HPV DNA检出率为14.89%(35/235),UU阴性HPV DNA检出率7.07%(8/113),两组数据比较,χ2=4.302 3,P<0.05,差异有统计学意义。第二组数据UUDNA拷贝数大于104 HPV检出率为17.75%(30/169),UU DNA拷贝数小于104HPV检出率为7.57%(5/66),两组数据比较χ2=3.877 3,P<0.05,差异有统计学意义。结论解脲支原体的感染与人乳头瘤病毒的感染具有相关性,UU感染会增加HPV感染机会,且随着UU含量的增加而增加。Objective To investigate the correlation of Ureaplasma urealyticum（UU）infection and human papillomavirus（HPV）infection.Methods 348 outpatients in the obstetrics and gynecology clinic of our hospital were performed the retrospective analysis.The cervical secretion samples were collected and simultaneously detected the common high risk types of HPV DNA（16,18,31,33,45,52,56,58）and UU DNA by using fluorescence quantitative PCRAB7300 detecting instrument.The two groups of data were set.In the first group,UU DNA positive was taken as the experimental group and UU DNA negative as the control group,the data in the two groups were performed the detection positive rate analysis of common high-risk HPV DNA.In the second group of data,UU DNA copy number greater than 104 was taken as the positive control and UU DNA copy number less than 104 as the negative control,two groups of data were performed the detection positive rate analysis of common in high-risk HPV DNA.Results In the first group of data,the UU DNA detection rate reached 67.5（235/348）,the HPV DNA detection rate with UU positive was 14.89%（35/235）,while which with UU negative was 7.07%（8/113）,the difference between the two groups of data had statistically significant（χ2=4.302 3,P〈0.05）.In the second group of data,the HPV detection rate with UUDNA copy number greater than104 was 17.75%（30/169）,while which with UU DNA copy number less than 104 was 7.57%（5/66）,the difference between the two groups of data was statistically significant（χ2=3.877 3,P〈0.05）.Conclusion UU infection has a correlation with HPV infection,UU infection will increase the probability of HPV infection,moreover with UU content increase,the HPV infection is increased.

关 键 词：解脲支原体 人乳头瘤病毒 DNA 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]