姐妹同患硬斑病合并桥本甲状腺炎二例  

Morphea complicated by Hashimoto＆#39;s thyroiditis in two sisters

作　　者：刘金鹏[1] 于晓虹[1] 杨国玲[1] 宋智琦[1] 

机构地区：[1]大连医科大学附属第一医院皮肤科,116011

出　　处：《中华皮肤科杂志》2015年第4期248-251,共4页Chinese Journal of Dermatology

摘　　要：报告姐妹俩同患硬斑病合并桥本甲状腺炎.例1女,64岁,颈前、躯干和双胫前皮疹5年,会阴部皮疹伴瘙痒4年,既往桥本甲状腺炎病史9年.体检：甲状腺Ⅰ度肿大,质韧,无突眼、胫前黏液水肿等表现.颈部、前胸淡红色斑片,后背部硬化萎缩,会阴部瓷白色斑块.皮损组织病理提示：（前胸）硬斑病,（外阴）硬化萎缩性苔藓.例2女,例1的妹妹,55岁,左乳下及腹部皮肤逐渐硬化萎缩4年,既往桥本甲状腺炎病史3年.体检：甲状腺Ⅰ度肿大,质韧,无突眼、胫前黏液水肿等表现.左乳下、腹部和后背中央皮肤色素减退,硬化萎缩.皮损组织病理提示：硬斑病.根据临床特点、组织病理、过碘酸-雪夫染色和甲状腺功能检查,2例均诊断为硬斑病合并桥本甲状腺炎.Morphea complicated by Hashimoto＆#39;s thyroiditis is reported in two sisters.Case 1：a 64-year-old female presented with skin rashes on the anterior neck,trunk and bilateral anterior shins for 5 years,itching skin rashes on the perineum for 4 years,and Hashimoto＆#39;s thyroiditis for 9 years.Physical examination revealed grade 1 enlargement of firm thyroid gland without exophthalmos or pretibial myxedema.Dermatological examination showed pink patches on the neck and breast,sclerosis and atrophy of skin over the back,porcelain-white patches on the perineum.Histopathological findings suggested the diagnosis of morphea on the breast and lichen sclerosus et atrophicus on the perineum.Case 2：a 55-year-old female,who was the younger sister of case 1,suffered from gradual sclerosis and atrophy of skin in the left inframammary region and abdominal region for 4 years,as well as Hashimoto＆#39;s thyroiditis for 3 years.Similarly,physical examination revealed grade 1 enlargement of firm thyroid gland without exophthalmos or pretibial myxedema.Hypopigmentation,sclerosis and atrophy of skin were observed in the left inframammary region,abdominal region and central back region.Histopathological examination suggested a diagnosis of morphea.According to the clinical and histopathological manifestations,periodic acid-Schiff staining and thyroid gland function test results,the 2 cases were both diagnosed as morphea complicated by Hashimoto＇s thyroiditis.

关 键 词：硬皮病 局部性 硬化萎缩苔藓 桥本病 疾病遗传易感性 病例报告 

分 类 号：R581.4[医药卫生—内分泌]