利妥昔单抗相关的间质性肺炎文献复习:附2例报告  

Rituximab-induced interstitial pneumonitis: report of two cases and literature review

作　　者：平宝红[1] 岳春燕[1] 朱阳敏[1] 高雅[1] 吴彬[1] 洪佳琼[1] 

机构地区：[1]南方医科大学南方医院惠侨科,广东广州510515

出　　处：《南方医科大学学报》2015年第1期129-132,共4页Journal of Southern Medical University

基　　金：国防科工委专项课题分题(B3320062101)

摘　　要：目的学习总结利妥昔单抗(美罗华,RTX)相关的间质性肺炎(RTX-IP)的疾病特点、发病机制及诊疗方法。方法通过相关检查并结合文献回顾,对2例在使用RTX治疗过程中发生IP的淋巴瘤患者进行病例分析及治疗。结果 2例患者在治疗后间质性肺炎病灶消失,后续原发病治疗过程顺利。结论 RTX-IP起病隐匿,病理机制不明,症状不典型,需引起临床医生重视。高分辨CT对其早期发现应用价值高,RTX增加了患者对机会菌的易感性可能是部分患者的发病机制。We report two cases of rituximab（RTX）- induced interstitial pneumonia in two lymphoma patients receiving RTX treatment. Interstitial pneumonia was successfully managed in these two cases after a one- week- long intervention with corresponding treatments without affecting further treatment of the primary disease. RTX- induced interstitial pneumonia is characterized by a latent onset with an unclear pathological mechanism and absence of typical symptoms. High-resolution CT scan can provide valuable evidence for early diagnosis of RTX- induced interstitial pneumonia, which might be attributed partially to an increased susceptibility to P. jirovecii and fungal infection due to prolonged RTX treatment.

关 键 词：利妥昔单抗 间质性肺炎 淋巴瘤 

分 类 号：R733.1[医药卫生—肿瘤]