膳食蛋氨酸摄入量与原发性肝癌的关系  

Associations between dietary intake of methionine and primary liver cancer risk

作　　者：陈晓玲[1] 周瑞芬[1] 兰秋野 武婷[1] 朱惠莲[1] 

机构地区：[1]中山大学公共卫生学院营养系,广东广州510080

出　　处：《热带医学杂志》2015年第2期156-160,共5页Journal of Tropical Medicine

基　　金：国家自然科学基金(81472966)

摘　　要：目的拟通过评估研究对象平均每日膳食蛋氨酸的摄入量,探讨膳食蛋氨酸摄入量与原发性肝癌的关系。方法通过病例对照研究的方法,收集315例原发性肝癌首诊病例以及在性别、年龄（±5岁）1∶1匹配的315例对照,使用问卷以面对面的访谈形式收集研究对象的一般资料、生活方式（吸烟、饮酒）及近1年的膳食情况,运用多因素非条件Logistic回归模型分析膳食蛋氨酸摄入量和原发性肝癌的关系。结果病例组膳食蛋氨酸的摄入量显著高于对照组（P〈0.001）;高膳食蛋氨酸摄入量能显著增加原发性肝癌的发病风险,高膳食蛋氨酸摄入量（Q4）与低膳食蛋氨酸摄入量（Q1）相比的OR值（比值比）是1.96（95%CI：1.09-3.55）;在不吸烟人群和不饮酒人群中,高膳食蛋氨酸摄入量均能显著增加原发性肝癌的发病风险（OR（Q4：Q1）;95%CI分别为2.63（1.12,6.19）和2.21（1.12,4.37）;而在吸烟和饮酒人群中,膳食蛋氨酸的摄入量对原发性肝癌的发病风险的影响差异均无统计学意义（P值均〉0.05）。结论高膳食蛋氨酸的摄入量可能增加原发性肝癌的发病风险。Objective Methionine is converted to homocysteine （HCY） by methylation. Hyperhomocysteinemia （HHcy） was reported significantly positively correlation with many chronic diseases such as cardiovascular disease and cancer. In our study, we evaluated the average daily dietary intake of methionine andinvestigated the association between dietary intake of methionine and risk of primary liver cancer （PLC）. Methods A case-control study was conducted with 315 PLC cases and 315 controls, 1：1 matched by sex and age （5-year interval）. Respondents completed a questionnaire included general characteristics and lifestyle behaviom （smoking and drinking） and a 78-item food-frequency questionnaire by face-to-face interview. Then we used an unconditional logistic regression to calculate multivariate-adjusted odds ratio （OR） and 95% confidence intervals（C/）. Results The methionine intake in cases was significantly higher than controls （P〈0.001）. Higher methionine intake was associated with increased PLC risk, the adjusted OR （95% CI） of PLC for individuals with highest as compared to lowest quartiles of intake was 1.96 （1.09-3.55）. Among non-smokers or non- drinkers, the positive association was only significant in tile highest quartile of methionine intake, where the ORs were 2.63（95%CI： 1.12-6.19） and 2.21（95%CI： 1.12-4.37）, respectively. However, no significant association between methionine intake and risk of PLC was observed among smokers and drinkers （P〉0.05）. Conclusion The present study suggests that higher consumption of methionine possibly increased the risk of primary liver cancer.

关 键 词：膳食蛋氨酸 原发性肝癌 发病风险 

分 类 号：R735.7[医药卫生—肿瘤]