隐匿性HBV感染人群治疗后体内HBV-DNA含量与血清转换研究  

Study about HBV-DNA levels and seroconversion in OBI patients after treatment

作　　者：王铁兵 陈海霞[2] 刘义 蔡威 

机构地区：[1]深圳市光明新区疾病预防控制中心,广东深圳518106 [2]深圳市人民医院,广东深圳518109

出　　处：《热带医学杂志》2015年第2期193-195,共3页Journal of Tropical Medicine

基　　金：深圳市医疗卫生类科研项目(201303250)

摘　　要：目的探讨隐匿性HBV感染人群治疗后体内HBV-DNA含量与血清转换相关性,为隐匿性HBV感染的诊断和预防提供参考。方法对2010年度深圳某医院体检人群中筛查到57例隐匿性HBV感染人群,进行2年核酸定量检测和血清学的跟踪分析。结果核酸定量结果:57例隐匿性HBV感染患者在经过抗病毒治疗或接种乙肝疫苗(乙肝免疫球蛋白)后,2011年和2012年随访监测患者体内病毒含量均值分别为2.74E4 copies/ml和2.73E4copies/ml,高值均低于4E5 copies/ml,相对2010年结果差异无统计学意义(P>0.05)。血清转换结果 :抗病毒治疗或接种乙肝疫苗(乙肝免疫球蛋白)对HBe Ab和HBc Ab等乙肝血清标志物在隐匿性HBV感染人群中分布差异无统计学意义;出现HBs Ab(+)+HBV-DNA(+)感染模式,提示病毒逃逸和/或病毒突变风险增加。结论通常的抗病毒治疗或接种乙肝疫苗可能对DBI的防治效果一般,且可能增加病毒逃逸和/或突变的风险。Objective To Study about HBV-DNA levels and seroconversion in serum of OBI patients after treatment, and provide reference for the diagnosis and prevention of OBI. Methods 57 cases of OBI were screened from health examination groups at Shenzhen People＇s Hospital in 2010,and follow-up research about HBV-DNA levels and seroconversion was carried out in following 2 years. Results The Results of HBV-DNA levels： HBV-DNA levels of 57OBI cases after antiviral therapy or hepatitis B vaccination （hepatitis B immune globulin） in 2011 and 2012 were 2.74E4 copies/ml and 2.73 E4 copies/ml, respectively. Compared with the level in 2010 change, there was no significant difference （P〉0.05）. The results of serum conversion： there was no significant influenceon HBV serum markers of HBeAb and HBcAb in OBI patients after antiviral therapy or hepatitis B vaccination （injection HBIG）. The risks of the virus escaping mutation were increasing because of the appearance of HBsAb （＋） ＋HBV-DNA （＋）model. Conclusion The changes of HBV-DNA levels and seroconversion in serum of OBI patients after treatment had no significant difference.

关 键 词：隐匿性 血清转换 突变 

分 类 号：R392.11[医药卫生—免疫学]