人腺病毒55型六邻体蛋白同源建模及B细胞抗原表位预测  

Homologous modeling and prediction of B cell antigen epitope of human adenovirus type 55 hexon protein

作　　者：刘振卫[1] 曲章义[1] 商蕾[1] 高虹[1] 王迎晨[1] 董妥 杨金峰[1] 于惠崧 

机构地区：[1]哈尔滨医科大学公共卫生学院卫生微生物学教研室,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2015年第1期8-12,共5页Journal of Harbin Medical University

基　　金：国家自然科学基金资助项目(81172725;31370074)

摘　　要：目的预测人腺病毒55型六邻体蛋白B细胞抗原表位。方法使用DNAStar软件Protean模块,PSIPRED在线服务器和SWISS-MODEL在线服务器联合预测人腺病毒55型六邻体蛋白B细胞抗原表位。结果构建了人腺病毒55型六邻体蛋白三级结构模型和预测得到5个候选的人腺病毒55型六邻体抗原表位。结论成功预测人腺病毒55型六邻体蛋白B细胞抗原表位,为进一步研制疫苗和检测试剂奠定了基础。Objective To predict the B cell antigen epitope of human adenovirus type 55（ HAd V-55） hexon protein. Methods The B cell antigen epitope of HAd V-55 hexon protein was predicted by DNAStar Protean,PSIPRED and SWISS-MODEL. Results A three-dimensional model of HAd V-55 hexon protein was constructed. Five of candidate antigen epitopes of HAd V-55 hexon protein were found out. Conclusion We predict the B cell antigen epitope of HAd V-55 hexon protein successfully,which will be advantageous for the development of vaccine and detection reagent.

关 键 词：人腺病毒55型 六邻体 B细胞抗原表位 同源建模 预测 

分 类 号：O641[理学—物理化学] R373.1[理学—化学]