乳腺浸润性导管癌中HER-2和Survivin蛋白表达相关性研究  

Correlation between the expressions of HER-2 and Survivin in invasive breast ductal cancer

作　　者：张红[1] 林哲洙[1] 毛晓韵[2] 陈浩[2] 王旭[2] 郭扬[2] 房月[3] 金锋[2] 

机构地区：[1]辽宁医学院附属第三医院肿瘤外科,辽宁锦州121000 [2]中国医科大学附属第一医院肿瘤外科普通外科教研室乳腺外科 [3]中国医科大学药学院药理学教研室,辽宁沈阳110001

出　　处：《哈尔滨医科大学学报》2015年第1期41-44,共4页Journal of Harbin Medical University

基　　金：国家自然科学基金资助项目(30950009);辽宁省科技厅博士科研启动基金项目(20091110);锦州市科技局计划项目(11B2E01)

摘　　要：目的研究乳腺癌组织中HER-2蛋白和Survivin蛋白表达的相关性及其机制。方法采用免疫组化技术和图像分析技术检测24例乳腺浸润性导管癌组织中HER-2、ERK1/2、p-ERK1/2、AKT、pAKT、Survivin蛋白的表达情况,对蛋白表达的相关性进行统计学分析。结果乳腺浸润性导管癌组织中HER-2蛋白和p-AKT、Survivin蛋白表达之间具有正相关性(P<0.01)。结论乳腺浸润性导管癌组织中HER-2蛋白和Survivin蛋白之间可能具有正向调节关系,且其关系可能通过细胞信号转导蛋白pAKT参与完成。Objective To study the relationship between HER-2 and Survivin expression in primary invasive ductal breast cancer and its mechanism. Methods Twenty-four invasive ductal breast biopsy samples were analyzed for the expression levels of HER-2,Survivin,ERK1 /2,p-ERK1 /2,AKT,and p-AKT proteins by immunohistochemistry and image analysis technology. The correlation of protein expressions was statistically analyzed. Results Immunohistochemistry and image analysis technology showed a significant correlation in protein levels among HER-2,p-AKT,and Survivin in the primary invasive ductal breast cancer tissues（ all P 0. 01）. Conclusion HER-2 expression significantly correlates with Survivin at the protein level in invasive ductal breast cancer tissues,and the correlation might act via p-AKT involved in.

关 键 词：乳腺癌 HER-2 SURVIVIN P-AKT 

分 类 号：R737.9[医药卫生—肿瘤]