数字化音乐胃电起搏治疗顽固性功能性消化不良重叠非糜烂性反流病的疗效观察  

Therapeutic efficacy of digital music gastric electrical pacing for refractory functional dyspepsia concomitant with non-erosive reflux disease

作　　者：冉亚梅 林玲[1] 何雨芩[1] 陈强[1] 纪雷[1] 郎秀琼 黄智勇[2] 杨敏[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所消化内科,重庆400042 [2]重庆大学通信工程学院,重庆400030

出　　处：《解放军医学杂志》2015年第3期212-216,共5页Medical Journal of Chinese People's Liberation Army

基　　金：第三军医大学科技成果转化基金(2010XZH-11/2013XZH-07)~~

摘　　要：目的观察数字化音乐胃电起搏治疗顽固性功能性消化不良(FD)重叠非糜烂性反流病(NERD)的临床疗效,以及其对患者心理健康状况和生活质量的影响。方法根据罗马Ⅲ标准及胃食管反流病的蒙特利尔共识意见,选取顽固性FD重叠NERD患者50例。采用数字化音乐胃电起搏进行治疗,每日治疗1次,每次45min,15d为1疗程。应用临床症状积分评估治疗前与治疗15d后的临床疗效。采用症状自评量表-SCL90评估患者心理健康状况及生活质量。结果与治疗前比较,治疗15d后患者上腹痛、上腹胀满、早饱、嗳气、呃逆、恶心、烧心、反酸(昼)、反酸(夜)、厌食、睡眠等11大临床症状均明显缓解,差异均有统计学意义(P<0.005),其显效率(有效率)分别为59.0%(100.0%)、59.3%(96.3%)、47.0%(94.1%)、61.3%(96.8%)、86.7%(100.0%)、80.0%(100.0%)、64.3%(92.9%)、73.7%(89.5%)、64.3%(85.7%)、90.0%(90.0%)、36.7%(93.3%),治疗后患者症状缓解的总有效率为94.4%,总显效率为65.7%。与治疗前比较,治疗15d后患者躯体化、强迫症状、抑郁、焦虑SCL90评分明显下降,其差异有统计学意义(P<0.01)。结论数字化音乐胃电起搏治疗顽固性FD重叠NERD有显著疗效,有望成为此类疾病治疗的新选择。Objective To study the clinical efficacy of digital music gastric electrical pacing for refractory functional dyspepsia concomitant with non-erosive reflux disease, and its effects on mental health and life-quality of the patients. Methods According to the Rome Ⅲ criteria and Montreal consensus in diagnosis of gastroesophageal reflux disease, 50 patients with concomitant refractory functional dyspepsia and non-erosive reflux disease were recruited. The clinical efficacy of digital music gastric electrical pacing were evaluated using the score of clinical symptoms before treatment and 15 days after treatment, and the mental health and life-quality of patients were assessed using symptom checklist 90. Results Main symptoms, including upper abdominal pain, abdominal fullness, early satiety, belching, hiccup, nausea, heartburn, acid reflux （daytime）, nocturnal acid reflux, loss of appetite and sleep, were significantly improved 15 days after treatment compared with those of pre-treatment, and there were statistically significant differences （all P〈0.005）. The significant response rate / response rate （efficacy rate） were 59.0%/100.0%, 59.3%/96.3%, 47.0%/94.1%, 61.3%/96.8 %, 86.7%/100.0%, 80.0%/100.0% 64.3%/92.9%, 73.7%/89.5%, 64.3%/85.7%, 90.0%/90.0%, 36.7%/93.3% respectively. After treatment for 15 days, the overall response rate of symptom relief was 94.4% in patients and the overall significant response rate was 65.7%. The symptom scores of somatization, obsessive-compulsiveness,depression, and anxiety were significantly improved, and the differences were statistically significant （all P〈0.01）. Conclusion The clinical efficacy of digital music gastric electrical pacing is significant for refractory functional dyspepsia concomitant with non- erosive reflux disease, and it is expected to be a new option for the treatment of this disease complex.

关 键 词：消化不良 胃食管反流 胃电起搏 

分 类 号：R573.9[医药卫生—消化系统]