胰腺癌手术治疗的临床评估(附89例分析)  

Predictors for resectability and survival in pancreatic cancer

作　　者：洪建国[1] 孙祺[1] 梁本甲[1] 王英杰[1] 马驰[1] 邹志进 高超[1] 王奔[1] 赵传宗[1] 贺兆斌[1] 彭程[1] 王家勇[1] 牛卫博[1] 牛军[1] 

机构地区：[1]山东大学齐鲁医院肝胆外科,山东济南250012

出　　处：《中国现代普通外科进展》2015年第1期43-46,共4页Chinese Journal of Current Advances in General Surgery

摘　　要：目的 :分析和总结胰腺癌的手术治疗经验,结合相关资料探讨胰腺癌可切除性的评估标准。方法:对2007年1月至2012年1月手术治疗胰腺癌患者的诊断和治疗进行回顾性分析。结合患者病程、临床症状和体征、肿瘤TSN分期和影像学检查等资料,随访患者是否死亡及死亡时间、原因等数据,对胰腺癌的可切除性进行评估。结果:89例胰腺癌中,50例首发症状为上腹部疼痛和/或上腹部饱胀不适。25例为皮肤巩膜黄染、皮肤瘙痒和茶色尿等症状。肿瘤分期为Ⅰ、Ⅱ期和术前影像学检查中提示肿瘤未侵犯血管和无远处转移的患者切除率较高。结论:术前影像学检查及肿瘤TSN分期可用于胰腺癌可切除性评估。Objective： In this article, we reported the surgical treatment results of pancreatic cancer patients in Qilu Hospital of Shandong University between January 2007 and January 2012.The main objective was to investigate the association of clinicopathological factors with resectability of pancreatic cancer. Methods： This study consisted of a retrospectively review of all cases with pancreatic cancer at Qilu hospital of Shandong university. We retrospectively analyzed the clinical data of 89 consecutive patients underwent surgical treatment at our hospital. All patients with pancreatic cancer treated by surgery between January 2007 and January 2012 were eligible for the study. Clinical data of 89 patients during hospital stay were analyzed, including age, gender, clinical symptoms, laboratory findings, results of imaging examinations, period of disease, methods of surgical treatment, and clinopathological data of tumor. Follow-up data was established by phone follow-up either directly to the patients or to families or referring physician. Questions were addressed in regard to all-cause death and the exact death time. We investigated the clinicopathological factors that could be associated with curative resection and overall survival after surgical treatment. Results： The study patients comprised 57 men and 32 women aged 20-80 years. Disease duration ranged from 5 days to 1/2 year. Four patents（4/89）had postoperative morbidity. The follow-up rate was 51.8% in these patients. The patients at early stage of TSN, without venous invasion and/or distal metastasis had higher resection rate. Conclusion： The stage of the tumor and modern radiological techniques are important in evaluation of respectability of pancreatic cancer. A lot of effort is needed to improve the long-term surgical treatment outcomes.

关 键 词：胰腺肿瘤 胰十二指肠切除术 手术评估 

分 类 号：R735.9[医药卫生—肿瘤]