MST4 Revealed a Molecular Brake to Prevent Overactive Inflammatory Responses  

作　　者：ZHOU Zhaoca 

机构地区：[1]Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

出　　处：《Bulletin of the Chinese Academy of Sciences》2015年第1期45-45,共1页中国科学院院刊（英文版）

基　　金：funded by the National Natural Science Foundation of China;the Ministry of Science and Technology of China;the CAS and the Science&Technology Commission of Shanghai Municipality

摘　　要：Innate immunity is the frontline of defense against pathogens.Upon detection of pathogen-associated molecular patterns,Toll-like receptors(TLRs)will initiate innate immune responses,like inflammation,via activating the adaptor molecule TRAF6 to remove pathogens.However,excessive or prolonged inflammatory responses can cause severe host damage or even death;meanwhile chronic inflammation could lead toInnate immunity is the frontline of defense against pathogens.Upon detection of pathogen-associated molecular patterns,Toll-like receptors（TLRs）will initiate innate immune responses,like inflammation,via activating the adaptor molecule TRAF6 to remove pathogens.However,excessive or prolonged inflammatory responses can cause severe host damage or even death;

关 键 词：炎症反应 分子 过度 TOLL样受体 刹车 先天性免疫 病原体 免疫反应 

分 类 号：R363[医药卫生—病理学]