PDT联合ranibizumab玻璃体腔注射治疗年龄相关性黄斑变性合并CNV  

PDT combined with intravitreal injection of ranibizumab treatment for age-related macular degeneration with CNV

作　　者：杨雪艳[1] 何锦贤[1] 梁先军[1] 曾胜[1] 

机构地区：[1]中国广东省佛山市中医院眼科,528000

出　　处：《国际眼科杂志》2015年第4期659-661,共3页International Eye Science

基　　金：2014年广东省建设中医药强省立项资助科研课题(No.20141272)~~

摘　　要：目的：观察PDT联合玻璃体腔注射ranibizumab（雷珠单抗）治疗老年性黄斑变性脉络膜新生血管（choroidal neovascularization,CNV）的疗效。方法：将符合纳入标准,经吲哚青绿脉络膜血管造影（indocyanine green angiography,ICGA）、光学相干断层扫描（optical coherence tomography,OCT）检查确诊为黄斑区脉络膜新生血管（CNV）患者27例27眼,经PDT治疗后3~7d内行ranibizumab玻璃体腔注射。观察治疗后1,3,6mo、末次随访时行最佳矫正视力、FFA、ICGA、OCT检查及有无并发症发生情况。结果：最佳矫正视力提高17眼（63%）,最佳矫正视力稳定6眼（22%）,最佳矫正视力下降4眼（15%）。27例27眼治疗前平均渗漏面积为1 005.69±105.47μm,治疗后1,3mo后平均875.54±103.27,423.37±79.68μm,与治疗前比较差异有统计学意义（P〈0.01）,视网膜黄斑中央厚度27例27眼治疗前平均厚度为485.58±122.59μm,治疗后1,3mo后平均398.84±105.32,297.74±89.18μm,与治疗前比较差异有统计学意义（P〈0.01）。结论：PDT封闭CNV后,联合玻璃体内腔内注射ranibizumab,有效阻断新生血管复发,减少PDT再次治疗次数和并发症,可提高治疗效果。AIM： To observe the curative effect of PDT combined with intravitreal injection of ranibizumab treatment for age-related macular degeneration with choroidal neovascularization（ CNV）.METHODS： In accordance with the inclusion criteria,by indocyanine green choroidalangiography（ ICGA） and optical coherence tomography（ OCT） examination confirmed the diagnosis of macular CNV in 27 patients（ 27eyes）,treated with PDT 3 ~ 7d professional intravitreal injection of ranibizumab. At 1,3,6mo after treatment,the results of best corrected visual acuity（ BCVA）,FFA,ICGA, OCT examination and complications were observed.RESULTS： The BCVA improved in 17 eyes（ 63%）,stable in 6 eyes（ 22%）,and decreased in 4 eyes（ 15%）.Before treatment,the average leakage area was 1 005. 69± 105. 47μm,it were 875. 54 ± 103. 27μm,and 423. 37 ±79. 68μm at 1 and 3mo after treatment, there were significant differences compared with before treatment（ P〈 0. 01）. Average central macular thickness of retina before treatment was 485. 58 ± 122. 59μm,and 398. 84 ±105. 32μm, 297. 74 ± 89. 18μ m at 1 and 3mo after treatment,there were significant differences compared with before treatment（ P 〈0. 01）.CONCLUSION： The method that PDT closed CNV combined with intravitreal injection of ranibizumab can effectively block angiogenesis recurrence, reduce the number of PDT treatment again and complications,improve the therapeutic effect.

关 键 词：PDT治疗 雷珠单抗 年龄相关性黄斑变性 脉络膜新生血管 

分 类 号：R774.5[医药卫生—眼科]