RVO黄斑水肿患者雷珠单抗治疗后脉络膜厚度的变化  

Changes in subfoveal choroidal thickness after intravitreal injections of ranibizumab for macular edema secondary to retinal vein occlusion

作　　者：张祺[1] 冯劼[1] 李培凤[1] 金翼[1] 陈思敏[1] 

机构地区：[1]中国湖北省武汉市第一医院眼科,430033

出　　处：《国际眼科杂志》2015年第4期712-713,共2页International Eye Science

摘　　要：目的:观察视网膜静脉阻塞(retinal vein occlusion,RVO)黄斑水肿患者雷珠单抗治疗后脉络膜厚度的变化。方法:RVO黄斑水肿患者36例36眼行雷珠单抗3+prn次玻璃体腔注射治疗。随访1a,观察患眼及对侧眼治疗前和治疗后中心凹下脉络膜厚度的变化。结果:治疗前、治疗后1,6,12mo时患眼平均中心凹下脉络膜厚度(Subfoveal choroidal thickness,SFCT)分别为246.7±115.0,220.5±102.0,198.3±114.0,212.6±96.0μm,差异有统计学意义(P<0.05)。对侧眼平均SFCT分别为229.4±108.0,226.3±107.0,228.6±127.0,223.6±101.0μm,对侧眼治疗前后中心凹下脉络膜厚度的变化无差异。结论:RVO黄斑水肿患者雷珠单抗治疗后中心凹下脉络膜厚度明显降低。雷珠单抗玻璃体腔注射治疗可能影响脉络膜血流状态。AIM： To observe the changes in subfoveal choroidal thickness（ SFCT） after intravitreal injections of ranibizumab（ IVR） for macular edema secondary to retinal vein occlusion（ RVO）.METHODS： Thirty- six eyes of 36 patients with macular edema secondary to RVO） were treated with 0. 5mg IVR monthly for 3mo and received additional IVR as needed over the following 1a period. SFCT of the all eyes（ the affected eyes with RVO and unaffected fellow eyes） was measured by enhanced depth imaging optical coherence tomography images before and after the IVR.RESULTS： The mean SFCT of the affected eyes with RVO decreased from 246. 7 ± 115. 0μm at baseline to 220. 5±102. 0μm at 1mo（ P 〈0. 05）,198. 3 ± 114. 0μm at 6mo（ P〈0. 01）,212. 6 ± 96. 0μm at 12mo（ P 〈0. 01）. Whereas the fellow eyes changed from 229. 4 ± 108. 0μm at baseline to226. 3 ± 107. 0μm at 1mo（ P 〉 0. 05）,228. 6 ± 127. 0μm at6mo（ P 〉 0. 05）,223. 6 ± 101. 0μm at 12mo（ P 〉 0. 05）.There were statistically significant difference between affected eyes with RVO and unaffected fellow eyes.CONCLUSION： The SFCT is decreased after IVR for macular edema secondary to RVO. IVR seems to affect the hemorheology of the choroid.

关 键 词：视网膜静脉阻塞 雷珠单抗 黄斑水肿 脉络膜厚度 

分 类 号：R774[医药卫生—眼科]