孤立性肺肿瘤应用立体定向体部放射治疗的疗效分析  

Efficacy analysis of stereotactic body radiation therapy on solitary pulmonary tumor

作　　者：伍勇[1] 曹小飞[1] 翁成荫[1] 甘庆权[1] 陈小君[1] 刘国龙[1] 

机构地区：[1]广州医科大学附属广州市第一人民医院肿瘤科,广州510180

出　　处：《广州医药》2015年第2期32-35,共4页Guangzhou Medical Journal

摘　　要：目的分析立体定向体部放射治疗（SBRJ）应用于孤立性肺肿瘤的疗效,探讨其临床价值。方法采用拓能（TOPSLANE）全身X线立体定向放射治疗系统治疗15例孤立性肺肿瘤患者,其中I期非小细胞肺癌患者8例,单个肺转移瘤患者7例。单次剂量为5～8Gy/次,每天1次,每周3次,共8～10次,总剂量50～64Gy,生物有效剂量（BED）75～115Gy。分析治疗的近期疗效、急性放射损伤和局部控制率。结果 3例患者完全缓解（20.0%）,10例患者部分缓解（66.7%）,2例患者病灶稳定（13.3%）,没有疾病进展的患者。15例患者总有效率为86.7%（13/15）。BED〈90Gy的患者有效率为33.3%,而BED〉90Gy的患者有效率为100%,差异有统计学意义（P〈0.05）。3例患者出现2级急性放射损伤,未见3级以上毒副反应。1年和2年局控率分别为92.3%和81.2%。结论 SBRT治疗孤立性肺肿瘤可获得较好的近期疗效和局部控制率,急性放射损伤较轻。Objective To analyze the efficacy of stereotactic body radiation therapy （SBRT） onsolitary pulmonary tumor and explore its clinical value. Methods TOPSLANE X-ray stereotactic body radiation therapy system was used for treat- ment of fifteen patients with solitary pulmonary tumor, including eight patients with stage I non-small cell lung cancer and seven patients with single lung metastasis. Fraction dose of 5 to 8Gy was prescribed once a day, three times a week, totally 8 to 10 times to a total dose of 50 to 64 Gy and biological effective dose （BED） of 75 to 115Gy. Short-term efficacy, acute radiation in- jury and local control rate were analyzed. Results After treatment, there were three patients with complete response （CR） （20. 0% ）, ten patients with partial response （PR） （66. 7% ）, tow patients with stable disease （SD） （ 13.3% ）, and no pa- tients with progressive disease （PD） . The total response rate was 86. 7% （13/15） . The response rate was 33.3% in patients with BED 〈90 Gy, while it was 100% in patients with BED 〉 90 Gy, and the difference was statistically significant （P 〈0. 05 ） Grade 2 acute radiation injuries were observed in three patients, and no toxicity greater than grade 3 was observed. The 1-year and 2-year local control rate was 92. 3% and 81.2%, respectively. Conclusion SBRT on solitary pulmonary tumor has good short-term efficacy and local control rate with mild acute radiation injury.

关 键 词：孤立性肺肿瘤 立体定向体部放射治疗 疗效 

分 类 号：R734.2[医药卫生—肿瘤]