FAK和VEGF-C在上皮性卵巢癌中的表达及临床意义  

Expression and Clinical Significance of FAK and VEGF-C in Epithelial Ovarian Cancer

作　　者：李明群[1] 董金菊[1] 郭红艳[1] 王华[1] 郭广林[1] 

机构地区：[1]湖北医药学院附属襄阳医院妇产科,湖北襄阳441000

出　　处：《湖北医药学院学报》2015年第1期43-47,F0002,共6页Journal of Hubei University of Medicine

摘　　要：目的:探讨上皮性卵巢癌中黏着斑激酶(focal adhesion kinase,FAK)和血管内皮生长因子C(vascular endothelial growth factor C,VEGF-C)蛋白表达的临床意义、化疗耐药性及二者之间的相互关系。方法:采用免疫组化染色,光镜观察FAK、VEGF-C在正常及恶性上皮性卵巢组织中的蛋白表达,结合临床病理资料进行综合分析。结果:正常及恶性上皮性卵巢组织中FAK、VEGF-C皆有表达,FAK和VEGF-C在卵巢癌组织中的表达明显高于正常卵巢组织(P<0.01)。FAK表达与病理分级、临床分期、淋巴结转移、不良预后及化疗耐药性明显相关(P<0.05),而与年龄、组织学类型无关(P>0.05);VEGF-C表达仅与淋巴结转移、不良预后及化疗耐药性相关(P<0.05),而与年龄、临床分期、病理分级、组织学类型无关(P>0.05)。FAK和VEGF-C的表达呈Spearman等级相关(r=0.462,P=0.001)。结论:FAK和VEGF-C在卵巢癌组织中的表达明显高于正常卵巢组织,它们以协同作用共同促进卵巢癌的浸润和转移,同时在卵巢癌化疗耐药中有着重要作用,可作为判断卵巢癌恶性程度及评估不良预后的重要指标。Objective To investigate the expression of focal adhesion kinase（ FAK） and vascular endothelial growth factor C（ VEGF-C） protein in human epithelial ovarian cancer and its clinical significance,explore their roles in the drug resistance of cancer cells treated with chemotherapy,and analyze the correlation between the expressions of FAK and VEGF-C. Methods The expression of FAK and VEGF-C in normal and malignant epithelial ovarian tissue were examined by immunohistochemical staining. The correlation between the expressions of FAK and VEGF-C combined with clinical pathologi data was comprehensively analyzed. Results FAK and VEGF-C were positively expressed in both normal and malignant epithelial ovarian tissue,and the expressions of FAK and VEGF-C in malignant tissue were obviously higher than those of normal tissue（ P〈 0. 01）. The expression of FAK was correlated with the pathological degree,clinical stage,lymphnode metastasis,unfavourable prognosis and chemotherapy resistance（ P〈 0. 05）,but not with age and histological types（ P〈 0. 05）. The expression of VEGF-C was only correlated with lymphnode metastasis,chemotherapy resistance and unfavourable prognosis（ P〈 0. 05）,but not correlated with the other clinical parameters（ P〉 0. 05）. Spearman rank correlation analysis showed a positive correlation between the expression of FAK and VEGF-C in malignant epithelial ovarian tissue（ r = 0. 462,P = 0. 001）.Conclusion The expression of FAK and VEGF-C in ovarian cancer tissue was higher than those of normal tissue,and FAK and VEGF-C may have a synergistic function in promoting the infiltration and metastasis of ovarian cancer. Meanwhile,FAK and VEGF-C may play important roles in the chemotherapy resistance,which could be the important indexes in judging malignant degree and evaluating unfavourable prognosis.

关 键 词：卵巢癌 黏着斑激酶 血管内皮生长因子C 免疫组织化学 化疗耐药 

分 类 号：R737.31[医药卫生—肿瘤]