75例胃癌患者中整合素β3与MMP-9的表达及其与预后关系的研究  

Clinical significance and prognosis of Integrinβ3 and MMP-9 expression in 75 cases with gastric carcinoma

作　　者：纪春才 靖昌庆[1] 

机构地区：[1]山东大学附属省立医院胃肠外科,山东济南250021 [2]山东省禹城市人民医院普外科,山东禹城251200

出　　处：《中国现代普通外科进展》2015年第2期90-93,共4页Chinese Journal of Current Advances in General Surgery

基　　金：山东省优秀中青年科学家科研奖励基金(BS2011YY046);山东省自然科学基金(ZR2011HM041);山东省科技攻关课题(2011GGB14158)

摘　　要：目的:检测75例胃癌患者肿瘤组织中整合素β3和基质金属蛋白酶-9(MMP-9)的表达,分析其与胃癌临床病理因素及预后的关系。方法:采用免疫组织化学Elivision二步法检测胃癌组织中整合素β3及MMP-9的表达。结果:胃癌组织中整合素β3及MMP-9呈阳性表达且两者呈正相关性。整合素β3及MMP-9的表达与胃癌根治术5年生存率有关(P<0.05)。结论:胃癌组织中整合素β3和MMP-9的表达有相关性,两者的表达水平可能用于评估胃癌患者根治术后的生存期。Objective： To analysis the relationship of integrin β3, MMP-9, clinicalpathological features and the prognosis in gastric cancer. Methods： Integrin β3 and MMP-9 in gastric cancer was detected by immunohistochemistry Elivision in 75 cases to verify the expression of integrin β3,MMP-9 and to analyze its relationship with clinical and pathological features and 5-year recurrence.Results： Integrin β3 and MMP-9 expressed in the intracellular and mem brane had the positive correlation in gastric carcinoma. The patients with positive integrin β3 expression had the negative relationship with 5-year recurrence-free（P=0.001）, and the MMP-9 also had the negative relationship with 5-year recurrence-free（P=0.001）. Conclusion： The integrin β3 and MMP-9 are positive expression in gastric carcinoma. The integrin β3 and MMP-9 positive expression must be closely positive relationship with 5-year recurrence-free in patients with gastric carcinoma.

关 键 词：胃肿瘤 整合素Β3 金属蛋白酶-9 

分 类 号：R735.2[医药卫生—肿瘤]