免疫防龋DNA疫苗动物实验研究进展  

Recent development of animal research on immunization anti-caries DNA vaccine

作　　者：童辉燕 程敏[1] 李文娟[1] 

机构地区：[1]吉林大学口腔医院预防口腔科,吉林长春130021

出　　处：《口腔医学》2015年第3期234-236,共3页Stomatology

摘　　要：龋病是以变形链球菌为主要致龋菌引起的口腔感染性疾病。有效地诱导机体产生针对变形链球菌的系统免疫和黏膜免疫,阻止细菌在牙面的粘附与聚集以及细菌在口腔内定植,是防止致龋菌感染的有效手段。应用于免疫防龋研究主要有主动免疫防龋和被动免疫防龋。本文主要论述主动免疫防龋疫苗中的防龋DNA疫苗的优缺点、研究进展及未来的发展前景。Dental caries is one of the most common bacterial infections,which is mainly caused by Mutans Streptococci. Effectively inducing the organism to produce systemic immunity and mucosal immunity against Mutans Streptococci,thus preventing bacterial adhesion and aggregation in the tooth surfaces and bacterial colonization in the oral cavity,is an effective way of preventing cariogenic bacteria infection. Immunization against dental caries mainly includes active immunization and passive immunization. The advantages and disadvantages,research progress and future prospects of anti-caries DNA vaccine are mainly discussed in this article.

关 键 词：DNA疫苗 靶向防龋 黏膜免疫 佐剂和运载系统 

分 类 号：R780.1[医药卫生—口腔医学]